Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity

Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li(+)). This review discusses recent evidence that shows PO acts via the multiple inositol polyphosphate phosphatase (MIPP) to regulate gene expression. As a consequence, PO...

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Autor principal: Harwood, Adrian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267164/
https://www.ncbi.nlm.nih.gov/pubmed/21222625
http://dx.doi.org/10.2174/187152711794653779
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author Harwood, Adrian J
author_facet Harwood, Adrian J
author_sort Harwood, Adrian J
collection PubMed
description Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li(+)). This review discusses recent evidence that shows PO acts via the multiple inositol polyphosphate phosphatase (MIPP) to regulate gene expression. As a consequence, PO inhibition causes both a transient, rapid increase in I(1,4,5)P(3) and a long-term elevation of IP signalling. This pathway is evolutionary conserved, being present in both the social amoeba Dictyostelium and human cell systems, and has potential implications for mental health.
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spelling pubmed-32671642012-01-30 Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity Harwood, Adrian J CNS Neurol Disord Drug Targets Article Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li(+)). This review discusses recent evidence that shows PO acts via the multiple inositol polyphosphate phosphatase (MIPP) to regulate gene expression. As a consequence, PO inhibition causes both a transient, rapid increase in I(1,4,5)P(3) and a long-term elevation of IP signalling. This pathway is evolutionary conserved, being present in both the social amoeba Dictyostelium and human cell systems, and has potential implications for mental health. Bentham Science Publishers 2011-05 /pmc/articles/PMC3267164/ /pubmed/21222625 http://dx.doi.org/10.2174/187152711794653779 Text en © 2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Harwood, Adrian J
Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
title Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
title_full Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
title_fullStr Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
title_full_unstemmed Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
title_short Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
title_sort prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267164/
https://www.ncbi.nlm.nih.gov/pubmed/21222625
http://dx.doi.org/10.2174/187152711794653779
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