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Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function
Pulmonary function measures reflect respiratory health and predict mortality, and are used in the diagnosis of chronic obstructive pulmonary disease (COPD). We tested genome-wide association with the forced expiratory volume in 1 second (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC)...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376/ https://www.ncbi.nlm.nih.gov/pubmed/21946350 http://dx.doi.org/10.1038/ng.941 |
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| author | Artigas, María Soler Loth, Daan W Wain, Louise V Gharib, Sina A Obeidat, Ma’en Tang, Wenbo Zhai, Guangju Zhao, Jing Hua Smith, Albert Vernon Huffman, Jennifer E Albrecht, Eva Jackson, Catherine M Evans, David M Cadby, Gemma Fornage, Myriam Manichaikul, Ani Lopez, Lorna M Johnson, Toby Aldrich, Melinda C Aspelund, Thor Barroso, Inês Campbell, Harry Cassano, Patricia A Couper, David J Eiriksdottir, Gudny Franceschini, Nora Garcia, Melissa Gieger, Christian Gislason, Gauti Kjartan Grkovic, Ivica Hammond, Christopher J Hancock, Dana B Harris, Tamara B Ramasamy, Adaikalavan Heckbert, Susan R Heliövaara, Markku Homuth, Georg Hysi, Pirro G James, Alan L Jankovic, Stipan Joubert, Bonnie R Karrasch, Stefan Klopp, Norman Koch, Beate Kritchevsky, Stephen B Launer, Lenore J Liu, Yongmei Loehr, Laura R Lohman, Kurt Loos, Ruth JF Lumley, Thomas Al Balushi, Khalid A Ang, Wei Q Barr, R Graham Beilby, John Blakey, John D Boban, Mladen Boraska, Vesna Brisman, Jonas Britton, John R Brusselle, Guy G Cooper, Cyrus Curjuric, Ivan Dahgam, Santosh Deary, Ian J Ebrahim, Shah Eijgelsheim, Mark Francks, Clyde Gaysina, Darya Granell, Raquel Gu, Xiangjun Hankinson, John L Hardy, Rebecca Harris, Sarah E Henderson, John Henry, Amanda Hingorani, Aroon D Hofman, Albert Holt, Patrick G Hui, Jennie Hunter, Michael L Imboden, Medea Jameson, Karen A Kerr, Shona M Kolcic, Ivana Kronenberg, Florian Liu, Jason Z Marchini, Jonathan McKeever, Tricia Morris, Andrew D Olin, Anna-Carin Porteous, David J Postma, Dirkje S Rich, Stephen S Ring, Susan M Rivadeneira, Fernando Rochat, Thierry Sayer, Avan Aihie Sayers, Ian Sly, Peter D Smith, George Davey Sood, Akshay Starr, John M Uitterlinden, André G Vonk, Judith M Wannamethee, S Goya Whincup, Peter H Wijmenga, Cisca Williams, O Dale Wong, Andrew Mangino, Massimo Marciante, Kristin D McArdle, Wendy L Meibohm, Bernd Morrison, Alanna C North, Kari E Omenaas, Ernst Palmer, Lyle J Pietiläinen, Kirsi H Pin, Isabelle Polašek, Ozren Pouta, Anneli Psaty, Bruce M Hartikainen, Anna-Liisa Rantanen, Taina Ripatti, Samuli Rotter, Jerome I Rudan, Igor Rudnicka, Alicja R Schulz, Holger Shin, So-Youn Spector, Tim D Surakka, Ida Vitart, Veronique Völzke, Henry Wareham, Nicholas J Warrington, Nicole M Wichmann, H-Erich Wild, Sarah H Wilk, Jemma B Wjst, Matthias Wright, Alan F Zgaga, Lina Zemunik, Tatijana Pennell, Craig E Nyberg, Fredrik Kuh, Diana Holloway, John W Boezen, H Marike Lawlor, Debbie A Morris, Richard W Probst-Hensch, Nicole Kaprio, Jaakko Wilson, James F Hayward, Caroline Kähönen, Mika Heinrich, Joachim Musk, Arthur W Jarvis, Deborah L Gläser, Sven Järvelin, Marjo-Riitta Stricker, Bruno H Ch Elliott, Paul O’Connor, George T Strachan, David P London, Stephanie J Hall, Ian P Gudnason, Vilmundur Tobin, Martin D |
| author_facet | Artigas, María Soler Loth, Daan W Wain, Louise V Gharib, Sina A Obeidat, Ma’en Tang, Wenbo Zhai, Guangju Zhao, Jing Hua Smith, Albert Vernon Huffman, Jennifer E Albrecht, Eva Jackson, Catherine M Evans, David M Cadby, Gemma Fornage, Myriam Manichaikul, Ani Lopez, Lorna M Johnson, Toby Aldrich, Melinda C Aspelund, Thor Barroso, Inês Campbell, Harry Cassano, Patricia A Couper, David J Eiriksdottir, Gudny Franceschini, Nora Garcia, Melissa Gieger, Christian Gislason, Gauti Kjartan Grkovic, Ivica Hammond, Christopher J Hancock, Dana B Harris, Tamara B Ramasamy, Adaikalavan Heckbert, Susan R Heliövaara, Markku Homuth, Georg Hysi, Pirro G James, Alan L Jankovic, Stipan Joubert, Bonnie R Karrasch, Stefan Klopp, Norman Koch, Beate Kritchevsky, Stephen B Launer, Lenore J Liu, Yongmei Loehr, Laura R Lohman, Kurt Loos, Ruth JF Lumley, Thomas Al Balushi, Khalid A Ang, Wei Q Barr, R Graham Beilby, John Blakey, John D Boban, Mladen Boraska, Vesna Brisman, Jonas Britton, John R Brusselle, Guy G Cooper, Cyrus Curjuric, Ivan Dahgam, Santosh Deary, Ian J Ebrahim, Shah Eijgelsheim, Mark Francks, Clyde Gaysina, Darya Granell, Raquel Gu, Xiangjun Hankinson, John L Hardy, Rebecca Harris, Sarah E Henderson, John Henry, Amanda Hingorani, Aroon D Hofman, Albert Holt, Patrick G Hui, Jennie Hunter, Michael L Imboden, Medea Jameson, Karen A Kerr, Shona M Kolcic, Ivana Kronenberg, Florian Liu, Jason Z Marchini, Jonathan McKeever, Tricia Morris, Andrew D Olin, Anna-Carin Porteous, David J Postma, Dirkje S Rich, Stephen S Ring, Susan M Rivadeneira, Fernando Rochat, Thierry Sayer, Avan Aihie Sayers, Ian Sly, Peter D Smith, George Davey Sood, Akshay Starr, John M Uitterlinden, André G Vonk, Judith M Wannamethee, S Goya Whincup, Peter H Wijmenga, Cisca Williams, O Dale Wong, Andrew Mangino, Massimo Marciante, Kristin D McArdle, Wendy L Meibohm, Bernd Morrison, Alanna C North, Kari E Omenaas, Ernst Palmer, Lyle J Pietiläinen, Kirsi H Pin, Isabelle Polašek, Ozren Pouta, Anneli Psaty, Bruce M Hartikainen, Anna-Liisa Rantanen, Taina Ripatti, Samuli Rotter, Jerome I Rudan, Igor Rudnicka, Alicja R Schulz, Holger Shin, So-Youn Spector, Tim D Surakka, Ida Vitart, Veronique Völzke, Henry Wareham, Nicholas J Warrington, Nicole M Wichmann, H-Erich Wild, Sarah H Wilk, Jemma B Wjst, Matthias Wright, Alan F Zgaga, Lina Zemunik, Tatijana Pennell, Craig E Nyberg, Fredrik Kuh, Diana Holloway, John W Boezen, H Marike Lawlor, Debbie A Morris, Richard W Probst-Hensch, Nicole Kaprio, Jaakko Wilson, James F Hayward, Caroline Kähönen, Mika Heinrich, Joachim Musk, Arthur W Jarvis, Deborah L Gläser, Sven Järvelin, Marjo-Riitta Stricker, Bruno H Ch Elliott, Paul O’Connor, George T Strachan, David P London, Stephanie J Hall, Ian P Gudnason, Vilmundur Tobin, Martin D |
| author_sort | Artigas, María Soler |
| collection | PubMed |
| description | Pulmonary function measures reflect respiratory health and predict mortality, and are used in the diagnosis of chronic obstructive pulmonary disease (COPD). We tested genome-wide association with the forced expiratory volume in 1 second (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in 48,201 individuals of European ancestry, with follow-up of top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P<5×10(−8)) with pulmonary function, in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1, and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function. |
| format | Online Article Text |
| id | pubmed-3267376 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-32673762012-05-01 Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function Artigas, María Soler Loth, Daan W Wain, Louise V Gharib, Sina A Obeidat, Ma’en Tang, Wenbo Zhai, Guangju Zhao, Jing Hua Smith, Albert Vernon Huffman, Jennifer E Albrecht, Eva Jackson, Catherine M Evans, David M Cadby, Gemma Fornage, Myriam Manichaikul, Ani Lopez, Lorna M Johnson, Toby Aldrich, Melinda C Aspelund, Thor Barroso, Inês Campbell, Harry Cassano, Patricia A Couper, David J Eiriksdottir, Gudny Franceschini, Nora Garcia, Melissa Gieger, Christian Gislason, Gauti Kjartan Grkovic, Ivica Hammond, Christopher J Hancock, Dana B Harris, Tamara B Ramasamy, Adaikalavan Heckbert, Susan R Heliövaara, Markku Homuth, Georg Hysi, Pirro G James, Alan L Jankovic, Stipan Joubert, Bonnie R Karrasch, Stefan Klopp, Norman Koch, Beate Kritchevsky, Stephen B Launer, Lenore J Liu, Yongmei Loehr, Laura R Lohman, Kurt Loos, Ruth JF Lumley, Thomas Al Balushi, Khalid A Ang, Wei Q Barr, R Graham Beilby, John Blakey, John D Boban, Mladen Boraska, Vesna Brisman, Jonas Britton, John R Brusselle, Guy G Cooper, Cyrus Curjuric, Ivan Dahgam, Santosh Deary, Ian J Ebrahim, Shah Eijgelsheim, Mark Francks, Clyde Gaysina, Darya Granell, Raquel Gu, Xiangjun Hankinson, John L Hardy, Rebecca Harris, Sarah E Henderson, John Henry, Amanda Hingorani, Aroon D Hofman, Albert Holt, Patrick G Hui, Jennie Hunter, Michael L Imboden, Medea Jameson, Karen A Kerr, Shona M Kolcic, Ivana Kronenberg, Florian Liu, Jason Z Marchini, Jonathan McKeever, Tricia Morris, Andrew D Olin, Anna-Carin Porteous, David J Postma, Dirkje S Rich, Stephen S Ring, Susan M Rivadeneira, Fernando Rochat, Thierry Sayer, Avan Aihie Sayers, Ian Sly, Peter D Smith, George Davey Sood, Akshay Starr, John M Uitterlinden, André G Vonk, Judith M Wannamethee, S Goya Whincup, Peter H Wijmenga, Cisca Williams, O Dale Wong, Andrew Mangino, Massimo Marciante, Kristin D McArdle, Wendy L Meibohm, Bernd Morrison, Alanna C North, Kari E Omenaas, Ernst Palmer, Lyle J Pietiläinen, Kirsi H Pin, Isabelle Polašek, Ozren Pouta, Anneli Psaty, Bruce M Hartikainen, Anna-Liisa Rantanen, Taina Ripatti, Samuli Rotter, Jerome I Rudan, Igor Rudnicka, Alicja R Schulz, Holger Shin, So-Youn Spector, Tim D Surakka, Ida Vitart, Veronique Völzke, Henry Wareham, Nicholas J Warrington, Nicole M Wichmann, H-Erich Wild, Sarah H Wilk, Jemma B Wjst, Matthias Wright, Alan F Zgaga, Lina Zemunik, Tatijana Pennell, Craig E Nyberg, Fredrik Kuh, Diana Holloway, John W Boezen, H Marike Lawlor, Debbie A Morris, Richard W Probst-Hensch, Nicole Kaprio, Jaakko Wilson, James F Hayward, Caroline Kähönen, Mika Heinrich, Joachim Musk, Arthur W Jarvis, Deborah L Gläser, Sven Järvelin, Marjo-Riitta Stricker, Bruno H Ch Elliott, Paul O’Connor, George T Strachan, David P London, Stephanie J Hall, Ian P Gudnason, Vilmundur Tobin, Martin D Nat Genet Article Pulmonary function measures reflect respiratory health and predict mortality, and are used in the diagnosis of chronic obstructive pulmonary disease (COPD). We tested genome-wide association with the forced expiratory volume in 1 second (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in 48,201 individuals of European ancestry, with follow-up of top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P<5×10(−8)) with pulmonary function, in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1, and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function. 2011-09-25 /pmc/articles/PMC3267376/ /pubmed/21946350 http://dx.doi.org/10.1038/ng.941 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Artigas, María Soler Loth, Daan W Wain, Louise V Gharib, Sina A Obeidat, Ma’en Tang, Wenbo Zhai, Guangju Zhao, Jing Hua Smith, Albert Vernon Huffman, Jennifer E Albrecht, Eva Jackson, Catherine M Evans, David M Cadby, Gemma Fornage, Myriam Manichaikul, Ani Lopez, Lorna M Johnson, Toby Aldrich, Melinda C Aspelund, Thor Barroso, Inês Campbell, Harry Cassano, Patricia A Couper, David J Eiriksdottir, Gudny Franceschini, Nora Garcia, Melissa Gieger, Christian Gislason, Gauti Kjartan Grkovic, Ivica Hammond, Christopher J Hancock, Dana B Harris, Tamara B Ramasamy, Adaikalavan Heckbert, Susan R Heliövaara, Markku Homuth, Georg Hysi, Pirro G James, Alan L Jankovic, Stipan Joubert, Bonnie R Karrasch, Stefan Klopp, Norman Koch, Beate Kritchevsky, Stephen B Launer, Lenore J Liu, Yongmei Loehr, Laura R Lohman, Kurt Loos, Ruth JF Lumley, Thomas Al Balushi, Khalid A Ang, Wei Q Barr, R Graham Beilby, John Blakey, John D Boban, Mladen Boraska, Vesna Brisman, Jonas Britton, John R Brusselle, Guy G Cooper, Cyrus Curjuric, Ivan Dahgam, Santosh Deary, Ian J Ebrahim, Shah Eijgelsheim, Mark Francks, Clyde Gaysina, Darya Granell, Raquel Gu, Xiangjun Hankinson, John L Hardy, Rebecca Harris, Sarah E Henderson, John Henry, Amanda Hingorani, Aroon D Hofman, Albert Holt, Patrick G Hui, Jennie Hunter, Michael L Imboden, Medea Jameson, Karen A Kerr, Shona M Kolcic, Ivana Kronenberg, Florian Liu, Jason Z Marchini, Jonathan McKeever, Tricia Morris, Andrew D Olin, Anna-Carin Porteous, David J Postma, Dirkje S Rich, Stephen S Ring, Susan M Rivadeneira, Fernando Rochat, Thierry Sayer, Avan Aihie Sayers, Ian Sly, Peter D Smith, George Davey Sood, Akshay Starr, John M Uitterlinden, André G Vonk, Judith M Wannamethee, S Goya Whincup, Peter H Wijmenga, Cisca Williams, O Dale Wong, Andrew Mangino, Massimo Marciante, Kristin D McArdle, Wendy L Meibohm, Bernd Morrison, Alanna C North, Kari E Omenaas, Ernst Palmer, Lyle J Pietiläinen, Kirsi H Pin, Isabelle Polašek, Ozren Pouta, Anneli Psaty, Bruce M Hartikainen, Anna-Liisa Rantanen, Taina Ripatti, Samuli Rotter, Jerome I Rudan, Igor Rudnicka, Alicja R Schulz, Holger Shin, So-Youn Spector, Tim D Surakka, Ida Vitart, Veronique Völzke, Henry Wareham, Nicholas J Warrington, Nicole M Wichmann, H-Erich Wild, Sarah H Wilk, Jemma B Wjst, Matthias Wright, Alan F Zgaga, Lina Zemunik, Tatijana Pennell, Craig E Nyberg, Fredrik Kuh, Diana Holloway, John W Boezen, H Marike Lawlor, Debbie A Morris, Richard W Probst-Hensch, Nicole Kaprio, Jaakko Wilson, James F Hayward, Caroline Kähönen, Mika Heinrich, Joachim Musk, Arthur W Jarvis, Deborah L Gläser, Sven Järvelin, Marjo-Riitta Stricker, Bruno H Ch Elliott, Paul O’Connor, George T Strachan, David P London, Stephanie J Hall, Ian P Gudnason, Vilmundur Tobin, Martin D Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| title | Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| title_full | Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| title_fullStr | Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| title_full_unstemmed | Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| title_short | Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| title_sort | genome-wide association and large scale follow-up identifies 16 new loci influencing lung function |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376/ https://www.ncbi.nlm.nih.gov/pubmed/21946350 http://dx.doi.org/10.1038/ng.941 |
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