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Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction

BACKGROUND: To define the dosimetric coverage of level I/II axillary volumes and the lung volume irradiated in postmastectomy radiotherapy (PMRT) following tissue expander placement. METHODS AND MATERIALS: Twenty-three patients were identified who had undergone postmastectomy radiotherapy with tange...

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Autores principales: Russo, James K, Armeson, Kent E, Rhome, Ryan, Spanos, Michele, Harper, Jennifer L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267695/
https://www.ncbi.nlm.nih.gov/pubmed/22204504
http://dx.doi.org/10.1186/1748-717X-6-179
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author Russo, James K
Armeson, Kent E
Rhome, Ryan
Spanos, Michele
Harper, Jennifer L
author_facet Russo, James K
Armeson, Kent E
Rhome, Ryan
Spanos, Michele
Harper, Jennifer L
author_sort Russo, James K
collection PubMed
description BACKGROUND: To define the dosimetric coverage of level I/II axillary volumes and the lung volume irradiated in postmastectomy radiotherapy (PMRT) following tissue expander placement. METHODS AND MATERIALS: Twenty-three patients were identified who had undergone postmastectomy radiotherapy with tangent only fields. All patients had pre-radiation tissue expander placement and expansion. Thirteen patients had bilateral expander reconstruction. The level I/II axillary volumes were contoured using the RTOG contouring atlas. The patient-specific variables of expander volume, superior-to-inferior location of expander, distance between expanders, expander angle and axillary volume were analyzed to determine their relationship to the axillary volume and lung volume dose. RESULTS: The mean coverage of the level I/II axillary volume by the 95% isodose line (V(D95%)) was 23.9% (range 0.3 - 65.4%). The mean Ipsilateral Lung V(D50% )was 8.8% (2.2-20.9). Ipsilateral and contralateral expander volume correlated to Axillary V(D95% )in patients with bilateral reconstruction (p = 0.01 and 0.006, respectively) but not those with ipsilateral only reconstruction (p = 0.60). Ipsilateral Lung V(D50% )correlated with angle of the expander from midline (p = 0.05). CONCLUSIONS: In patients undergoing PMRT with tissue expanders, incidental doses delivered by tangents to the axilla, as defined by the RTOG contouring atlas, do not provide adequate coverage. The posterior-superior region of level I and II is the region most commonly underdosed. Axillary volume coverage increased with increasing expander volumes in patients with bilateral reconstruction. Lung dose increased with increasing expander angle from midline. This information should be considered both when placing expanders and when designing PMRT tangent only treatment plans by contouring and targeting the axilla volume when axillary treatment is indicated.
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spelling pubmed-32676952012-01-28 Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction Russo, James K Armeson, Kent E Rhome, Ryan Spanos, Michele Harper, Jennifer L Radiat Oncol Research BACKGROUND: To define the dosimetric coverage of level I/II axillary volumes and the lung volume irradiated in postmastectomy radiotherapy (PMRT) following tissue expander placement. METHODS AND MATERIALS: Twenty-three patients were identified who had undergone postmastectomy radiotherapy with tangent only fields. All patients had pre-radiation tissue expander placement and expansion. Thirteen patients had bilateral expander reconstruction. The level I/II axillary volumes were contoured using the RTOG contouring atlas. The patient-specific variables of expander volume, superior-to-inferior location of expander, distance between expanders, expander angle and axillary volume were analyzed to determine their relationship to the axillary volume and lung volume dose. RESULTS: The mean coverage of the level I/II axillary volume by the 95% isodose line (V(D95%)) was 23.9% (range 0.3 - 65.4%). The mean Ipsilateral Lung V(D50% )was 8.8% (2.2-20.9). Ipsilateral and contralateral expander volume correlated to Axillary V(D95% )in patients with bilateral reconstruction (p = 0.01 and 0.006, respectively) but not those with ipsilateral only reconstruction (p = 0.60). Ipsilateral Lung V(D50% )correlated with angle of the expander from midline (p = 0.05). CONCLUSIONS: In patients undergoing PMRT with tissue expanders, incidental doses delivered by tangents to the axilla, as defined by the RTOG contouring atlas, do not provide adequate coverage. The posterior-superior region of level I and II is the region most commonly underdosed. Axillary volume coverage increased with increasing expander volumes in patients with bilateral reconstruction. Lung dose increased with increasing expander angle from midline. This information should be considered both when placing expanders and when designing PMRT tangent only treatment plans by contouring and targeting the axilla volume when axillary treatment is indicated. BioMed Central 2011-12-28 /pmc/articles/PMC3267695/ /pubmed/22204504 http://dx.doi.org/10.1186/1748-717X-6-179 Text en Copyright ©2011 Russo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Russo, James K
Armeson, Kent E
Rhome, Ryan
Spanos, Michele
Harper, Jennifer L
Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
title Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
title_full Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
title_fullStr Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
title_full_unstemmed Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
title_short Dose to level I and II axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
title_sort dose to level i and ii axillary lymph nodes and lung by tangential field radiation in patients undergoing postmastectomy radiation with tissue expander reconstruction
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267695/
https://www.ncbi.nlm.nih.gov/pubmed/22204504
http://dx.doi.org/10.1186/1748-717X-6-179
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