Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing

Dyskeratosis congenita (DC) is a rare bone marrow failure syndrome in which hematopoietic defects are the main cause of mortality. The most studied gene responsible for DC pathogenesis is DKC1 while mutations in several other genes encoding components of the H/ACA RNP telomerase complex, which is in...

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Detalles Bibliográficos
Autores principales: Zhang, Ying, Morimoto, Kenji, Danilova, Nadia, Zhang, Bo, Lin, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267717/
https://www.ncbi.nlm.nih.gov/pubmed/22299032
http://dx.doi.org/10.1371/journal.pone.0030188

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