The PI3-Kinase/mTOR-Targeting Drug NVP-BEZ235 Inhibits Growth and IgE-Dependent Activation of Human Mast Cells and Basophils

The phosphoinositide 3-kinase (PI3-kinase) and the mammalian target of rapamycin (mTOR) are two major signaling molecules involved in growth and activation of mast cells (MC) and basophils (BA). We examined the effects of the dual PI3-kinase/mTOR blocker NVP-BEZ235 on growth of normal and neoplastic...

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Detalles Bibliográficos
Autores principales: Blatt, Katharina, Herrmann, Harald, Mirkina, Irina, Hadzijusufovic, Emir, Peter, Barbara, Strommer, Sabine, Hoermann, Gregor, Mayerhofer, Matthias, Hoetzenecker, Konrad, Klepetko, Walter, Ghanim, Viviane, Marth, Katharina, Füreder, Thorsten, Wacheck, Volker, Valenta, Rudolf, Valent, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267720/
https://www.ncbi.nlm.nih.gov/pubmed/22299028
http://dx.doi.org/10.1371/journal.pone.0029925

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