Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects. HIF activity is determined by the oxygen regulated α-subunits HIF-1α or HIF-2α. Both are regulated by oxygen dependent degradatio...

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Detalles Bibliográficos
Autores principales: Schietke, Ruth E., Hackenbeck, Thomas, Tran, Maxine, Günther, Regina, Klanke, Bernd, Warnecke, Christina L., Knaup, Karl X., Shukla, Deepa, Rosenberger, Christian, Koesters, Robert, Bachmann, Sebastian, Betz, Peter, Schley, Gunnar, Schödel, Johannes, Willam, Carsten, Winkler, Thomas, Amann, Kerstin, Eckardt, Kai-Uwe, Maxwell, Patrick, Wiesener, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267769/
https://www.ncbi.nlm.nih.gov/pubmed/22299048
http://dx.doi.org/10.1371/journal.pone.0031034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267769/
https://www.ncbi.nlm.nih.gov/pubmed/22299048
http://dx.doi.org/10.1371/journal.pone.0031034

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