Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia

L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signali...

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Autores principales: Subramaniam, Srinivasa, Napolitano, Francesco, Mealer, Robert G., Kim, Seyun, Errico, Francesco, Barrow, Roxanne, Shahani, Neelam, Tyagi, Richa, Snyder, Solomon H., Usiello, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267880/
https://www.ncbi.nlm.nih.gov/pubmed/22179112
http://dx.doi.org/10.1038/nn.2994
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author Subramaniam, Srinivasa
Napolitano, Francesco
Mealer, Robert G.
Kim, Seyun
Errico, Francesco
Barrow, Roxanne
Shahani, Neelam
Tyagi, Richa
Snyder, Solomon H.
Usiello, Alessandro
author_facet Subramaniam, Srinivasa
Napolitano, Francesco
Mealer, Robert G.
Kim, Seyun
Errico, Francesco
Barrow, Roxanne
Shahani, Neelam
Tyagi, Richa
Snyder, Solomon H.
Usiello, Alessandro
author_sort Subramaniam, Srinivasa
collection PubMed
description L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signaling and diminished dyskinesia but maintain motor improvement upon L–DOPA treatment, implying therapeutic benefit for Rhes–binding drugs.
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spelling pubmed-32678802012-08-01 Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia Subramaniam, Srinivasa Napolitano, Francesco Mealer, Robert G. Kim, Seyun Errico, Francesco Barrow, Roxanne Shahani, Neelam Tyagi, Richa Snyder, Solomon H. Usiello, Alessandro Nat Neurosci Article L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signaling and diminished dyskinesia but maintain motor improvement upon L–DOPA treatment, implying therapeutic benefit for Rhes–binding drugs. 2011-12-18 /pmc/articles/PMC3267880/ /pubmed/22179112 http://dx.doi.org/10.1038/nn.2994 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Subramaniam, Srinivasa
Napolitano, Francesco
Mealer, Robert G.
Kim, Seyun
Errico, Francesco
Barrow, Roxanne
Shahani, Neelam
Tyagi, Richa
Snyder, Solomon H.
Usiello, Alessandro
Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
title Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
title_full Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
title_fullStr Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
title_full_unstemmed Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
title_short Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
title_sort rhes, a striatal–enriched small g–protein, mediates mtor signaling and l–dopa–induced dyskinesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267880/
https://www.ncbi.nlm.nih.gov/pubmed/22179112
http://dx.doi.org/10.1038/nn.2994
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