Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia

L–DOPA–induced dyskinesia, the rate–limiting side–effect in the therapy of Parkinson’s Disease, is mediated by activation of mTOR signaling in the striatum. We show that Rhes, a striatal–specific protein, binds to and activates mTOR. Moreover, Rhes deleted mice manifest reduced striatal mTOR signali...

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Detalles Bibliográficos
Autores principales: Subramaniam, Srinivasa, Napolitano, Francesco, Mealer, Robert G., Kim, Seyun, Errico, Francesco, Barrow, Roxanne, Shahani, Neelam, Tyagi, Richa, Snyder, Solomon H., Usiello, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267880/
https://www.ncbi.nlm.nih.gov/pubmed/22179112
http://dx.doi.org/10.1038/nn.2994

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