Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis

The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells,...

Descripción completa

Detalles Bibliográficos
Autores principales: Khavinson, V. Kh., Polyakova, V. O., Linkova, N. S., Dudkov, A. V., Kvetnoy, I. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268020/
https://www.ncbi.nlm.nih.gov/pubmed/22312461
http://dx.doi.org/10.4061/2011/517137
_version_ 1782222340287889408
author Khavinson, V. Kh.
Polyakova, V. O.
Linkova, N. S.
Dudkov, A. V.
Kvetnoy, I. M.
author_facet Khavinson, V. Kh.
Polyakova, V. O.
Linkova, N. S.
Dudkov, A. V.
Kvetnoy, I. M.
author_sort Khavinson, V. Kh.
collection PubMed
description The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells.
format Online
Article
Text
id pubmed-3268020
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher SAGE-Hindawi Access to Research
record_format MEDLINE/PubMed
spelling pubmed-32680202012-02-06 Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis Khavinson, V. Kh. Polyakova, V. O. Linkova, N. S. Dudkov, A. V. Kvetnoy, I. M. J Amino Acids Research Article The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells. SAGE-Hindawi Access to Research 2011 2011-11-28 /pmc/articles/PMC3268020/ /pubmed/22312461 http://dx.doi.org/10.4061/2011/517137 Text en Copyright © 2011 V. Kh. Khavinson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khavinson, V. Kh.
Polyakova, V. O.
Linkova, N. S.
Dudkov, A. V.
Kvetnoy, I. M.
Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
title Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
title_full Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
title_fullStr Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
title_full_unstemmed Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
title_short Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
title_sort peptides regulate cortical thymocytes differentiation, proliferation, and apoptosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268020/
https://www.ncbi.nlm.nih.gov/pubmed/22312461
http://dx.doi.org/10.4061/2011/517137
work_keys_str_mv AT khavinsonvkh peptidesregulatecorticalthymocytesdifferentiationproliferationandapoptosis
AT polyakovavo peptidesregulatecorticalthymocytesdifferentiationproliferationandapoptosis
AT linkovans peptidesregulatecorticalthymocytesdifferentiationproliferationandapoptosis
AT dudkovav peptidesregulatecorticalthymocytesdifferentiationproliferationandapoptosis
AT kvetnoyim peptidesregulatecorticalthymocytesdifferentiationproliferationandapoptosis

Ejemplares similares