Cargando…

Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats

In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor st...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hyun Joo, Nam, Yunjun, Koh, Chin Su, Im, Changkyun, Seo, In Seok, Choi, Seungjin, Shin, Hyung-Cheul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268153/
https://www.ncbi.nlm.nih.gov/pubmed/22355264
http://dx.doi.org/10.5607/en.2011.20.4.189
_version_ 1782222358472294400
author Lee, Hyun Joo
Nam, Yunjun
Koh, Chin Su
Im, Changkyun
Seo, In Seok
Choi, Seungjin
Shin, Hyung-Cheul
author_facet Lee, Hyun Joo
Nam, Yunjun
Koh, Chin Su
Im, Changkyun
Seo, In Seok
Choi, Seungjin
Shin, Hyung-Cheul
author_sort Lee, Hyun Joo
collection PubMed
description In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor stimulator. Odorants are: (i) plain air as a reference (Blank), (ii) 2-Heptanone (HEP), (iii) Isopropylbenzene (IB). Our results indicated that a plain air did not cause any change in the concentrations of oxygenated (Δ[HbO(2)]) and deoxygenated hemoglobin (Δ[Hbr]), but HEP and IB induced strong changes. Furthermore, these odor-specific changes had regional differences within the MOB. Our results suggest that NIRS technology might be a useful tool to identify of various odorants in a non-invasive manner using animals which has a superb olfactory system.
format Online
Article
Text
id pubmed-3268153
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The Korean Society for Brain and Neural Science
record_format MEDLINE/PubMed
spelling pubmed-32681532012-02-21 Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats Lee, Hyun Joo Nam, Yunjun Koh, Chin Su Im, Changkyun Seo, In Seok Choi, Seungjin Shin, Hyung-Cheul Exp Neurobiol Original Article In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor stimulator. Odorants are: (i) plain air as a reference (Blank), (ii) 2-Heptanone (HEP), (iii) Isopropylbenzene (IB). Our results indicated that a plain air did not cause any change in the concentrations of oxygenated (Δ[HbO(2)]) and deoxygenated hemoglobin (Δ[Hbr]), but HEP and IB induced strong changes. Furthermore, these odor-specific changes had regional differences within the MOB. Our results suggest that NIRS technology might be a useful tool to identify of various odorants in a non-invasive manner using animals which has a superb olfactory system. The Korean Society for Brain and Neural Science 2011-12 2011-12-29 /pmc/articles/PMC3268153/ /pubmed/22355264 http://dx.doi.org/10.5607/en.2011.20.4.189 Text en Copyright © Experimental Neurobiology 2011. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Hyun Joo
Nam, Yunjun
Koh, Chin Su
Im, Changkyun
Seo, In Seok
Choi, Seungjin
Shin, Hyung-Cheul
Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
title Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
title_full Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
title_fullStr Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
title_full_unstemmed Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
title_short Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats
title_sort odor-dependent hemodynamic responses measured with nirs in the main olfactory bulb of anesthetized rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268153/
https://www.ncbi.nlm.nih.gov/pubmed/22355264
http://dx.doi.org/10.5607/en.2011.20.4.189
work_keys_str_mv AT leehyunjoo odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats
AT namyunjun odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats
AT kohchinsu odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats
AT imchangkyun odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats
AT seoinseok odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats
AT choiseungjin odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats
AT shinhyungcheul odordependenthemodynamicresponsesmeasuredwithnirsinthemainolfactorybulbofanesthetizedrats