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Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis
PURPOSE: To assess the clinical outcomes of cyclosporine treatment for noninfectious uveitis. METHODS: A retrospective review of medical records was completed for 182 noninfectious uveitis patients who were treated with cyclosporine between January 2001 and August 2010. Data was obtained relevant to...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Ophthalmological Society
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268164/ https://www.ncbi.nlm.nih.gov/pubmed/22323881 http://dx.doi.org/10.3341/kjo.2012.26.1.21 |
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author | Lee, Sun Ho Chung, Hum Yu, Hyeong Gon |
author_facet | Lee, Sun Ho Chung, Hum Yu, Hyeong Gon |
author_sort | Lee, Sun Ho |
collection | PubMed |
description | PURPOSE: To assess the clinical outcomes of cyclosporine treatment for noninfectious uveitis. METHODS: A retrospective review of medical records was completed for 182 noninfectious uveitis patients who were treated with cyclosporine between January 2001 and August 2010. Data was obtained relevant to demographic characteristics, anatomic classification, and laterality of uveitis, associated systemic disorder, dosage of cyclosporine and prednisolone, usage of other immunosuppressive drugs, visual acuity (VA), control of uveitic activity, and adverse effects during the cyclosporine use. RESULTS: Uveitic activity was controlled to a level of minimal inflammation in 89.0% and completely in 78.6% of patients by the median duration of 49 and 98 days, respectively. Prednisolone-sparing (dose ≤10 mg) control of inflammation equal to or less than the minimal activity was achieved in 75.3% of patients. VA was aggravated more than 0.2 logarithm of the minimum angle of resolution in 17.3% of eyes in spite of cyclosporine treatment for the mean follow-up of 698.4 days. Dose reduction and cessation of cyclosporine was required only in 3.3% and 9.3%, respectively, due to the intolerable toxicity, although 44.0% of patients experienced mild to moderate adverse effects. CONCLUSIONS: Cyclosporine combined with corticosteroids or other immunosuppressive drugs as needed is an effective treatment for noninfectious uveitis, thus minimizing the adverse effects of corticosteroids and other toxic drugs. However, careful monitoring for the toxicity of cyclosporine is needed, because a small group of patients cannot tolerate its toxicity. |
format | Online Article Text |
id | pubmed-3268164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Ophthalmological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-32681642012-02-10 Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis Lee, Sun Ho Chung, Hum Yu, Hyeong Gon Korean J Ophthalmol Original Article PURPOSE: To assess the clinical outcomes of cyclosporine treatment for noninfectious uveitis. METHODS: A retrospective review of medical records was completed for 182 noninfectious uveitis patients who were treated with cyclosporine between January 2001 and August 2010. Data was obtained relevant to demographic characteristics, anatomic classification, and laterality of uveitis, associated systemic disorder, dosage of cyclosporine and prednisolone, usage of other immunosuppressive drugs, visual acuity (VA), control of uveitic activity, and adverse effects during the cyclosporine use. RESULTS: Uveitic activity was controlled to a level of minimal inflammation in 89.0% and completely in 78.6% of patients by the median duration of 49 and 98 days, respectively. Prednisolone-sparing (dose ≤10 mg) control of inflammation equal to or less than the minimal activity was achieved in 75.3% of patients. VA was aggravated more than 0.2 logarithm of the minimum angle of resolution in 17.3% of eyes in spite of cyclosporine treatment for the mean follow-up of 698.4 days. Dose reduction and cessation of cyclosporine was required only in 3.3% and 9.3%, respectively, due to the intolerable toxicity, although 44.0% of patients experienced mild to moderate adverse effects. CONCLUSIONS: Cyclosporine combined with corticosteroids or other immunosuppressive drugs as needed is an effective treatment for noninfectious uveitis, thus minimizing the adverse effects of corticosteroids and other toxic drugs. However, careful monitoring for the toxicity of cyclosporine is needed, because a small group of patients cannot tolerate its toxicity. The Korean Ophthalmological Society 2012-02 2012-01-14 /pmc/articles/PMC3268164/ /pubmed/22323881 http://dx.doi.org/10.3341/kjo.2012.26.1.21 Text en © 2012 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Sun Ho Chung, Hum Yu, Hyeong Gon Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis |
title | Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis |
title_full | Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis |
title_fullStr | Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis |
title_full_unstemmed | Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis |
title_short | Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis |
title_sort | clinical outcomes of cyclosporine treatment for noninfectious uveitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268164/ https://www.ncbi.nlm.nih.gov/pubmed/22323881 http://dx.doi.org/10.3341/kjo.2012.26.1.21 |
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