The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases

Misfolding and abnormal aggregation of proteins in the brain are implicated in the pathogenesis of various neurodegenerative diseases including Alzheimer's, Parkinson's, and the polyglutamine (polyQ) diseases. In the polyQ diseases, an abnormally expanded polyQ stretch triggers misfolding...

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Detalles Bibliográficos
Autores principales: Popiel, H. Akiko, Burke, James R., Strittmatter, Warren J., Oishi, Shinya, Fujii, Nobutaka, Takeuchi, Toshihide, Toda, Tatsushi, Wada, Keiji, Nagai, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268222/
https://www.ncbi.nlm.nih.gov/pubmed/22312459
http://dx.doi.org/10.4061/2011/265084

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