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Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor

The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A(2)α (cPLA(2)α). Signaling mediated by this class of bioactive lipids, which are collectively referred to as eicosanoids, has numerous effects in...

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Detalles Bibliográficos
Autores principales:	Noha, Stefan M., Jazzar, Bianca, Kuehnl, Susanne, Rollinger, Judith M., Stuppner, Hermann, Schaible, Anja M., Werz, Oliver, Wolber, Gerhard, Schuster, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268354/ https://www.ncbi.nlm.nih.gov/pubmed/22192589 http://dx.doi.org/10.1016/j.bmcl.2011.11.093

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