Cargando…

A Novel Role for α-Tocopherol Transfer Protein (α-TTP) in Protecting against Chloroquine Toxicity

Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases. Clinical treatment with CQ is often accompanied by serious side effects such as hepatitis and retinopathy. As a weak base, CQ accumulates in intracellular acidic organelles, raises the pH...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shichiri, Mototada, Kono, Nozomu, Shimanaka, Yuta, Tanito, Masaki, Rotzoll, Daisy E., Yoshida, Yasukazu, Hagihara, Yoshihisa, Tamai, Hiroshi, Arai, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268449/ https://www.ncbi.nlm.nih.gov/pubmed/22147702 http://dx.doi.org/10.1074/jbc.M111.321281

Ejemplares similares

Probucol-Induced α-Tocopherol Deficiency Protects Mice against Malaria Infection
por: Herbas, Maria Shirely, et al.
Publicado: (2015)

Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols()
por: Nishio, Keiko, et al.
Publicado: (2013)

Significance of Singlet Oxygen Molecule in Pathologies
por: Murotomi, Kazutoshi, et al.
Publicado: (2023)

Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques
por: Shichiri, Mototada, et al.
Publicado: (2019)

Engineering Tocopherol Selectivity in α-TTP: A Combined In Vitro/In Silico Study
por: Helbling, Rachel E., et al.
Publicado: (2012)

Alpha-Tocopherol Transfer Protein (α-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice
por: Lim, Yunsook, et al.
Publicado: (2007)

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP(3) Signaling
por: Buckles, Thomas C., et al.
Publicado: (2017)

Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol
por: Anegawa, Daisuke, et al.
Publicado: (2021)

Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo
por: Yoshida, Yasukazu, et al.
Publicado: (2013)

Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides
por: Vermeer, Louic S., et al.
Publicado: (2012)

β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α(IIb)β(3) Headpiece
por: Lin, Fu-Yang, et al.
Publicado: (2016)

Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release
por: Hatano, Noriyuki, et al.
Publicado: (2012)

Early diagnosis of type 2 diabetes based on multiple biomarkers and non-invasive indices
por: Umeno, Aya, et al.
Publicado: (2018)

The α-tocopherol status and expression of α-tocopherol-related proteins in methionine-choline deficient rats treated with vitamin E
por: Miyazaki, Hiroshi, et al.
Publicado: (2014)

Integral membrane protein structure: transmembrane α-helices as autonomous folding domains: Current opinion in structural biology 1993, 3: 532–540
por: Popot, Jean-Luc
Publicado: (1993)

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
por: Saito, Yoshiro, et al.
Publicado: (2015)

Characterization of the Interactions between Fluoroquinolone Antibiotics and Lipids: a Multitechnique Approach
por: Bensikaddour, Hayet, et al.
Publicado: (2008)

Water-Membrane Partition Thermodynamics of an Amphiphilic Lipopeptide: An Enthalpy-Driven Hydrophobic Effect
por: Gorfe, Alemayehu A., et al.
Publicado: (2008)

Investigation of Domain Formation in Sphingomyelin/Cholesterol/POPC Mixtures by Fluorescence Resonance Energy Transfer and Monte Carlo Simulations
por: Frazier, Monica L., et al.
Publicado: (2007)

SARS Coronavirus E Protein in Phospholipid Bilayers: An X-Ray Study
por: Khattari, Z., et al.
Publicado: (2006)

Surfactant Protein A Forms Extensive Lattice-Like Structures on 1,2-Dipalmitoylphosphatidylcholine/Rough-Lipopolysaccharide- Mixed Monolayers
por: García-Verdugo, Ignacio, et al.
Publicado: (2007)

Influence of Monolayer-Monolayer Coupling on the Phase Behavior of a Fluid Lipid Bilayer
por: Wagner, Alexander J., et al.
Publicado: (2007)

Interactions Between a Voltage Sensor and a Toxin via Multiscale Simulations
por: Wee, Chze Ling, et al.
Publicado: (2010)

Two Conserved Residues Are Important for Inducing Highly Ordered Membrane Domains by the Transmembrane Domain of Influenza Hemagglutinin
por: Ge, Mingtao, et al.
Publicado: (2011)

Structure Prediction of the Second Extracellular Loop in G-Protein-Coupled Receptors
por: Kmiecik, Sebastian, et al.
Publicado: (2014)

Raft Formation in Lipid Bilayers Coupled to Curvature
por: Sadeghi, Sina, et al.
Publicado: (2014)

Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions
por: Budin, Itay, et al.
Publicado: (2014)

Crystal Structures of the L(1), L(2), N, and O States of pharaonis Halorhodopsin
por: Kouyama, Tsutomu, et al.
Publicado: (2015)

MPP1 as a Factor Regulating Phase Separation in Giant Plasma Membrane-Derived Vesicles
por: Podkalicka, Joanna, et al.
Publicado: (2015)

Bud-Neck Scaffolding as a Possible Driving Force in ESCRT-Induced Membrane Budding
por: Mercker, Moritz, et al.
Publicado: (2015)

In Situ Determination of Structure and Fluctuations of Coexisting Fluid Membrane Domains
por: Heftberger, Peter, et al.
Publicado: (2015)

Revealing Assembly of a Pore-Forming Complex Using Single-Cell Kinetic Analysis and Modeling
por: Bischofberger, Mirko, et al.
Publicado: (2016)

A Role for Weak Electrostatic Interactions in Peripheral Membrane Protein Binding
por: Khan, Hanif M., et al.
Publicado: (2016)

MreB-Dependent Organization of the E. coli Cytoplasmic Membrane Controls Membrane Protein Diffusion
por: Oswald, Felix, et al.
Publicado: (2016)

Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor
por: Windisch, Dirk, et al.
Publicado: (2015)

Bending Rigidities and Interdomain Forces in Membranes with Coexisting Lipid Domains
por: Kollmitzer, Benjamin, et al.
Publicado: (2015)

PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties
por: Leite, Natália Bueno, et al.
Publicado: (2015)

Protonation Dynamics on Lipid Nanodiscs: Influence of the Membrane Surface Area and External Buffers
por: Xu, Lei, et al.
Publicado: (2016)

Identification of Bifurcations from Observations of Noisy Biological Oscillators
por: Salvi, Joshua D., et al.
Publicado: (2016)

Modulating Vesicle Adhesion by Electric Fields
por: Steinkühler, Jan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4qu5fui4psmv877dlc80ko65o1