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Non-Coding RNAs in Neural Networks, REST-Assured
In the nervous system, several key steps in cellular complexity and development are regulated by non-coding RNAs (ncRNAs) and the repressor element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF). REST recruits gene regulatory complexes to regulatory sequences, among...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268567/ https://www.ncbi.nlm.nih.gov/pubmed/22303307 http://dx.doi.org/10.3389/fgene.2011.00008 |
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author | Rossbach, Michael |
author_facet | Rossbach, Michael |
author_sort | Rossbach, Michael |
collection | PubMed |
description | In the nervous system, several key steps in cellular complexity and development are regulated by non-coding RNAs (ncRNAs) and the repressor element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF). REST recruits gene regulatory complexes to regulatory sequences, among them the repressor element-1/neuron-restrictive silencer element, and mediates developmental stage-specific gene expression or repression, chromatin (re-)organization or silencing for protein-coding genes as well as for several ncRNAs like microRNAs, short interfering RNAs or long ncRNAs. NcRNAs are far from being just transcriptional noise and are involved in chromatin accessibility, transcription and post-transcriptional processing, trafficking, or RNA editing. REST and its cofactor CoREST are both highly regulated through various ncRNAs. The importance of the correct regulation within the ncRNA network, the ncRNAome, is demonstrated when it comes to a deregulation of REST and/or ncRNAs associated with molecular pathophysiology underlying diverse disorders including neurodegenerative diseases or brain tumors. |
format | Online Article Text |
id | pubmed-3268567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32685672012-02-02 Non-Coding RNAs in Neural Networks, REST-Assured Rossbach, Michael Front Genet Genetics In the nervous system, several key steps in cellular complexity and development are regulated by non-coding RNAs (ncRNAs) and the repressor element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF). REST recruits gene regulatory complexes to regulatory sequences, among them the repressor element-1/neuron-restrictive silencer element, and mediates developmental stage-specific gene expression or repression, chromatin (re-)organization or silencing for protein-coding genes as well as for several ncRNAs like microRNAs, short interfering RNAs or long ncRNAs. NcRNAs are far from being just transcriptional noise and are involved in chromatin accessibility, transcription and post-transcriptional processing, trafficking, or RNA editing. REST and its cofactor CoREST are both highly regulated through various ncRNAs. The importance of the correct regulation within the ncRNA network, the ncRNAome, is demonstrated when it comes to a deregulation of REST and/or ncRNAs associated with molecular pathophysiology underlying diverse disorders including neurodegenerative diseases or brain tumors. Frontiers Research Foundation 2011-02-28 /pmc/articles/PMC3268567/ /pubmed/22303307 http://dx.doi.org/10.3389/fgene.2011.00008 Text en Copyright © 2011 Rossbach. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Genetics Rossbach, Michael Non-Coding RNAs in Neural Networks, REST-Assured |
title | Non-Coding RNAs in Neural Networks, REST-Assured |
title_full | Non-Coding RNAs in Neural Networks, REST-Assured |
title_fullStr | Non-Coding RNAs in Neural Networks, REST-Assured |
title_full_unstemmed | Non-Coding RNAs in Neural Networks, REST-Assured |
title_short | Non-Coding RNAs in Neural Networks, REST-Assured |
title_sort | non-coding rnas in neural networks, rest-assured |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268567/ https://www.ncbi.nlm.nih.gov/pubmed/22303307 http://dx.doi.org/10.3389/fgene.2011.00008 |
work_keys_str_mv | AT rossbachmichael noncodingrnasinneuralnetworksrestassured |