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Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits

Parent-of-origin effects (POE) such as genomic imprinting influence growth and body composition in livestock, rodents, and humans. Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in Angus × Brahman cattle crossbreds. We ident...

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Autores principales: Imumorin, Ikhide G., Kim, Eun-Hee, Lee, Yun-Mi, De Koning, Dirk-Jan, van Arendonk, Johan A., De Donato, Marcos, Taylor, Jeremy F., Kim, Jong-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268597/
https://www.ncbi.nlm.nih.gov/pubmed/22303340
http://dx.doi.org/10.3389/fgene.2011.00044
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author Imumorin, Ikhide G.
Kim, Eun-Hee
Lee, Yun-Mi
De Koning, Dirk-Jan
van Arendonk, Johan A.
De Donato, Marcos
Taylor, Jeremy F.
Kim, Jong-Joo
author_facet Imumorin, Ikhide G.
Kim, Eun-Hee
Lee, Yun-Mi
De Koning, Dirk-Jan
van Arendonk, Johan A.
De Donato, Marcos
Taylor, Jeremy F.
Kim, Jong-Joo
author_sort Imumorin, Ikhide G.
collection PubMed
description Parent-of-origin effects (POE) such as genomic imprinting influence growth and body composition in livestock, rodents, and humans. Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in Angus × Brahman cattle crossbreds. We identified 24 POE–QTL on 15 Bos taurus autosomes (BTAs) of which six were significant at 5% genome-wide (GW) level and 18 at the 5% chromosome-wide (CW) significance level. Six QTL were paternally expressed while 15 were maternally expressed. Three QTL influencing post-weaning growth map to the proximal end of BTA2 (linkage region of 0–9 cM; genomic region of 5.0–10.8 Mb), for which only one imprinted ortholog is known so far in the human and mouse genomes, and therefore may potentially represent a novel imprinted region. The detected QTL individually explained 1.4 ∼ 5.1% of each trait’s phenotypic variance. Comparative in silico analysis of bovine genomic locations show that 32 out of 1,442 known mammalian imprinted genes from human and mouse homologs map to the identified QTL regions. Although several of the 32 genes have been associated with quantitative traits in cattle, only two (GNAS and PEG3) have experimental proof of being imprinted in cattle. These results lend additional support to recent reports that POE on quantitative traits in mammals may be more common than previously thought, and strengthen the need to identify and experimentally validate cattle orthologs of imprinted genes so as to investigate their effects on quantitative traits.
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spelling pubmed-32685972012-02-02 Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits Imumorin, Ikhide G. Kim, Eun-Hee Lee, Yun-Mi De Koning, Dirk-Jan van Arendonk, Johan A. De Donato, Marcos Taylor, Jeremy F. Kim, Jong-Joo Front Genet Genetics Parent-of-origin effects (POE) such as genomic imprinting influence growth and body composition in livestock, rodents, and humans. Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in Angus × Brahman cattle crossbreds. We identified 24 POE–QTL on 15 Bos taurus autosomes (BTAs) of which six were significant at 5% genome-wide (GW) level and 18 at the 5% chromosome-wide (CW) significance level. Six QTL were paternally expressed while 15 were maternally expressed. Three QTL influencing post-weaning growth map to the proximal end of BTA2 (linkage region of 0–9 cM; genomic region of 5.0–10.8 Mb), for which only one imprinted ortholog is known so far in the human and mouse genomes, and therefore may potentially represent a novel imprinted region. The detected QTL individually explained 1.4 ∼ 5.1% of each trait’s phenotypic variance. Comparative in silico analysis of bovine genomic locations show that 32 out of 1,442 known mammalian imprinted genes from human and mouse homologs map to the identified QTL regions. Although several of the 32 genes have been associated with quantitative traits in cattle, only two (GNAS and PEG3) have experimental proof of being imprinted in cattle. These results lend additional support to recent reports that POE on quantitative traits in mammals may be more common than previously thought, and strengthen the need to identify and experimentally validate cattle orthologs of imprinted genes so as to investigate their effects on quantitative traits. Frontiers Research Foundation 2011-07-12 /pmc/articles/PMC3268597/ /pubmed/22303340 http://dx.doi.org/10.3389/fgene.2011.00044 Text en Copyright © 2011 Imumorin, Kim, Lee, De Koning, van Arendonk, De Donato, Taylor and Kim. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Genetics
Imumorin, Ikhide G.
Kim, Eun-Hee
Lee, Yun-Mi
De Koning, Dirk-Jan
van Arendonk, Johan A.
De Donato, Marcos
Taylor, Jeremy F.
Kim, Jong-Joo
Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
title Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
title_full Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
title_fullStr Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
title_full_unstemmed Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
title_short Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits
title_sort genome scan for parent-of-origin qtl effects on bovine growth and carcass traits
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268597/
https://www.ncbi.nlm.nih.gov/pubmed/22303340
http://dx.doi.org/10.3389/fgene.2011.00044
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