Enteric alpha defensins in norm and pathology

Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses o...

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Detalles Bibliográficos
Autores principales: Lisitsyn, Nikolai A, Bukurova, Yulia A, Nikitina, Inna G, Krasnov, George S, Sykulev, Yuri, Beresten, Sergey F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268740/
https://www.ncbi.nlm.nih.gov/pubmed/22236533
http://dx.doi.org/10.1186/1476-0711-11-1
Descripción
Sumario:Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.

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