Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens

We have previously observed that all known HIV-1 broadly neutralizing antibodies (bnAbs) are highly divergent from germline antibodies in contrast to bnAbs against Hendra virus, Nipah virus and SARS coronavirus (SARS CoV). We have hypothesized that because the germline antibodies are so different fr...

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Detalles Bibliográficos
Autores principales: Chen, Weizao, Streaker, Emily D., Russ, Daniel E., Feng, Yang, Prabakaran, Ponraj, Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268823/
https://www.ncbi.nlm.nih.gov/pubmed/22226962
http://dx.doi.org/10.1016/j.bbrc.2011.12.089

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