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Application of multiple forms of mechanical loading to human osteoblasts reveals increased ATP release in response to fluid flow in 3D cultures and differential regulation of immediate early genes
ATP is actively released into the extracellular environment from a variety of cell types in response to mechanical stimuli. This is particularly true in bone where mechanically induced ATP release leads to immediate early gene activation to regulate bone remodelling; however there is no consensus as...
Autores principales: | Rumney, R.M.H., Sunters, A., Reilly, G.C., Gartland, A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268859/ https://www.ncbi.nlm.nih.gov/pubmed/22176713 http://dx.doi.org/10.1016/j.jbiomech.2011.11.036 |
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