The JAK/STAT Pathway Is Involved in Synaptic Plasticity

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulat...

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Autores principales: Nicolas, Céline S., Peineau, Stéphane, Amici, Mascia, Csaba, Zsolt, Fafouri, Assia, Javalet, Charlotte, Collett, Valerie J., Hildebrandt, Lars, Seaton, Gillian, Choi, Sun-Lim, Sim, Su-Eon, Bradley, Clarrisa, Lee, Kyungmin, Zhuo, Min, Kaang, Bong-Kiun, Gressens, Pierre, Dournaud, Pascal, Fitzjohn, Stephen M., Bortolotto, Zuner A., Cho, Kwangwook, Collingridge, Graham L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268861/
https://www.ncbi.nlm.nih.gov/pubmed/22284190
http://dx.doi.org/10.1016/j.neuron.2011.11.024
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author Nicolas, Céline S.
Peineau, Stéphane
Amici, Mascia
Csaba, Zsolt
Fafouri, Assia
Javalet, Charlotte
Collett, Valerie J.
Hildebrandt, Lars
Seaton, Gillian
Choi, Sun-Lim
Sim, Su-Eon
Bradley, Clarrisa
Lee, Kyungmin
Zhuo, Min
Kaang, Bong-Kiun
Gressens, Pierre
Dournaud, Pascal
Fitzjohn, Stephen M.
Bortolotto, Zuner A.
Cho, Kwangwook
Collingridge, Graham L.
author_facet Nicolas, Céline S.
Peineau, Stéphane
Amici, Mascia
Csaba, Zsolt
Fafouri, Assia
Javalet, Charlotte
Collett, Valerie J.
Hildebrandt, Lars
Seaton, Gillian
Choi, Sun-Lim
Sim, Su-Eon
Bradley, Clarrisa
Lee, Kyungmin
Zhuo, Min
Kaang, Bong-Kiun
Gressens, Pierre
Dournaud, Pascal
Fitzjohn, Stephen M.
Bortolotto, Zuner A.
Cho, Kwangwook
Collingridge, Graham L.
author_sort Nicolas, Céline S.
collection PubMed
description The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.
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spelling pubmed-32688612012-02-06 The JAK/STAT Pathway Is Involved in Synaptic Plasticity Nicolas, Céline S. Peineau, Stéphane Amici, Mascia Csaba, Zsolt Fafouri, Assia Javalet, Charlotte Collett, Valerie J. Hildebrandt, Lars Seaton, Gillian Choi, Sun-Lim Sim, Su-Eon Bradley, Clarrisa Lee, Kyungmin Zhuo, Min Kaang, Bong-Kiun Gressens, Pierre Dournaud, Pascal Fitzjohn, Stephen M. Bortolotto, Zuner A. Cho, Kwangwook Collingridge, Graham L. Neuron Article The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain. Cell Press 2012-01-26 /pmc/articles/PMC3268861/ /pubmed/22284190 http://dx.doi.org/10.1016/j.neuron.2011.11.024 Text en © 2012 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Nicolas, Céline S.
Peineau, Stéphane
Amici, Mascia
Csaba, Zsolt
Fafouri, Assia
Javalet, Charlotte
Collett, Valerie J.
Hildebrandt, Lars
Seaton, Gillian
Choi, Sun-Lim
Sim, Su-Eon
Bradley, Clarrisa
Lee, Kyungmin
Zhuo, Min
Kaang, Bong-Kiun
Gressens, Pierre
Dournaud, Pascal
Fitzjohn, Stephen M.
Bortolotto, Zuner A.
Cho, Kwangwook
Collingridge, Graham L.
The JAK/STAT Pathway Is Involved in Synaptic Plasticity
title The JAK/STAT Pathway Is Involved in Synaptic Plasticity
title_full The JAK/STAT Pathway Is Involved in Synaptic Plasticity
title_fullStr The JAK/STAT Pathway Is Involved in Synaptic Plasticity
title_full_unstemmed The JAK/STAT Pathway Is Involved in Synaptic Plasticity
title_short The JAK/STAT Pathway Is Involved in Synaptic Plasticity
title_sort jak/stat pathway is involved in synaptic plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268861/
https://www.ncbi.nlm.nih.gov/pubmed/22284190
http://dx.doi.org/10.1016/j.neuron.2011.11.024
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