Cargando…

Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study

BACKGROUND: European ecologic studies suggest higher socioeconomic status is associated with higher incidence of type 1 diabetes. Using data from a case-control study of diabetes among racially/ethnically diverse youth in the United States (U.S.), we aimed to evaluate the independent impact of neigh...

Descripción completa

Detalles Bibliográficos
Autores principales: Liese, Angela D, Puett, Robin C, Lamichhane, Archana P, Nichols, Michele D, Dabelea, Dana, Lawson, Andrew B, Porter, Dwayne E, Hibbert, James D, D'Agostino, Ralph B, Mayer-Davis, Elizabeth J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269381/
https://www.ncbi.nlm.nih.gov/pubmed/22230476
http://dx.doi.org/10.1186/1476-072X-11-1
_version_ 1782222467295608832
author Liese, Angela D
Puett, Robin C
Lamichhane, Archana P
Nichols, Michele D
Dabelea, Dana
Lawson, Andrew B
Porter, Dwayne E
Hibbert, James D
D'Agostino, Ralph B
Mayer-Davis, Elizabeth J
author_facet Liese, Angela D
Puett, Robin C
Lamichhane, Archana P
Nichols, Michele D
Dabelea, Dana
Lawson, Andrew B
Porter, Dwayne E
Hibbert, James D
D'Agostino, Ralph B
Mayer-Davis, Elizabeth J
author_sort Liese, Angela D
collection PubMed
description BACKGROUND: European ecologic studies suggest higher socioeconomic status is associated with higher incidence of type 1 diabetes. Using data from a case-control study of diabetes among racially/ethnically diverse youth in the United States (U.S.), we aimed to evaluate the independent impact of neighborhood characteristics on type 1 diabetes risk. Data were available for 507 youth with type 1 diabetes and 208 healthy controls aged 10-22 years recruited in South Carolina and Colorado in 2003-2006. Home addresses were used to identify Census tracts of residence. Neighborhood-level variables were obtained from 2000 U.S. Census. Multivariate generalized linear mixed models were applied. RESULTS: Controlling for individual risk factors (age, gender, race/ethnicity, infant feeding, birth weight, maternal age, number of household residents, parental education, income, state), higher neighborhood household income (p = 0.005), proportion of population in managerial jobs (p = 0.02), with at least high school education (p = 0.005), working outside the county (p = 0.04) and vehicle ownership (p = 0.03) were each independently associated with increased odds of type 1 diabetes. Conversely, higher percent minority population (p = 0.0003), income from social security (p = 0.002), proportion of crowded households (0.0497) and poverty (p = 0.008) were associated with a decreased odds. CONCLUSIONS: Our study suggests that neighborhood characteristics related to greater affluence, occupation, and education are associated with higher type 1 diabetes risk. Further research is needed to understand mechanisms underlying the influence of neighborhood context.
format Online
Article
Text
id pubmed-3269381
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-32693812012-02-01 Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study Liese, Angela D Puett, Robin C Lamichhane, Archana P Nichols, Michele D Dabelea, Dana Lawson, Andrew B Porter, Dwayne E Hibbert, James D D'Agostino, Ralph B Mayer-Davis, Elizabeth J Int J Health Geogr Research BACKGROUND: European ecologic studies suggest higher socioeconomic status is associated with higher incidence of type 1 diabetes. Using data from a case-control study of diabetes among racially/ethnically diverse youth in the United States (U.S.), we aimed to evaluate the independent impact of neighborhood characteristics on type 1 diabetes risk. Data were available for 507 youth with type 1 diabetes and 208 healthy controls aged 10-22 years recruited in South Carolina and Colorado in 2003-2006. Home addresses were used to identify Census tracts of residence. Neighborhood-level variables were obtained from 2000 U.S. Census. Multivariate generalized linear mixed models were applied. RESULTS: Controlling for individual risk factors (age, gender, race/ethnicity, infant feeding, birth weight, maternal age, number of household residents, parental education, income, state), higher neighborhood household income (p = 0.005), proportion of population in managerial jobs (p = 0.02), with at least high school education (p = 0.005), working outside the county (p = 0.04) and vehicle ownership (p = 0.03) were each independently associated with increased odds of type 1 diabetes. Conversely, higher percent minority population (p = 0.0003), income from social security (p = 0.002), proportion of crowded households (0.0497) and poverty (p = 0.008) were associated with a decreased odds. CONCLUSIONS: Our study suggests that neighborhood characteristics related to greater affluence, occupation, and education are associated with higher type 1 diabetes risk. Further research is needed to understand mechanisms underlying the influence of neighborhood context. BioMed Central 2012-01-09 /pmc/articles/PMC3269381/ /pubmed/22230476 http://dx.doi.org/10.1186/1476-072X-11-1 Text en Copyright ©2012 Liese et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Liese, Angela D
Puett, Robin C
Lamichhane, Archana P
Nichols, Michele D
Dabelea, Dana
Lawson, Andrew B
Porter, Dwayne E
Hibbert, James D
D'Agostino, Ralph B
Mayer-Davis, Elizabeth J
Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study
title Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study
title_full Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study
title_fullStr Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study
title_full_unstemmed Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study
title_short Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study
title_sort neighborhood level risk factors for type 1 diabetes in youth: the search case-control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269381/
https://www.ncbi.nlm.nih.gov/pubmed/22230476
http://dx.doi.org/10.1186/1476-072X-11-1
work_keys_str_mv AT lieseangelad neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT puettrobinc neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT lamichhanearchanap neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT nicholsmicheled neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT dabeleadana neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT lawsonandrewb neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT porterdwaynee neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT hibbertjamesd neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT dagostinoralphb neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy
AT mayerdaviselizabethj neighborhoodlevelriskfactorsfortype1diabetesinyouththesearchcasecontrolstudy