Virulence of newcastle disease virus: what is known so far?

In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its...

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Autores principales: Dortmans, Jos CFM, Koch, Guus, Rottier, Peter JM, Peeters, Ben PH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269386/
https://www.ncbi.nlm.nih.gov/pubmed/22195547
http://dx.doi.org/10.1186/1297-9716-42-122
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author Dortmans, Jos CFM
Koch, Guus
Rottier, Peter JM
Peeters, Ben PH
author_facet Dortmans, Jos CFM
Koch, Guus
Rottier, Peter JM
Peeters, Ben PH
author_sort Dortmans, Jos CFM
collection PubMed
description In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors.
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spelling pubmed-32693862012-02-01 Virulence of newcastle disease virus: what is known so far? Dortmans, Jos CFM Koch, Guus Rottier, Peter JM Peeters, Ben PH Vet Res Review In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors. BioMed Central 2011 2011-12-23 /pmc/articles/PMC3269386/ /pubmed/22195547 http://dx.doi.org/10.1186/1297-9716-42-122 Text en Copyright ©2011 Dortmans et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Dortmans, Jos CFM
Koch, Guus
Rottier, Peter JM
Peeters, Ben PH
Virulence of newcastle disease virus: what is known so far?
title Virulence of newcastle disease virus: what is known so far?
title_full Virulence of newcastle disease virus: what is known so far?
title_fullStr Virulence of newcastle disease virus: what is known so far?
title_full_unstemmed Virulence of newcastle disease virus: what is known so far?
title_short Virulence of newcastle disease virus: what is known so far?
title_sort virulence of newcastle disease virus: what is known so far?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269386/
https://www.ncbi.nlm.nih.gov/pubmed/22195547
http://dx.doi.org/10.1186/1297-9716-42-122
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