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Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity

The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and genes. ncRNAs are also becoming central for u...

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Autor principal: Frías-Lasserre, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269699/
https://www.ncbi.nlm.nih.gov/pubmed/22312265
http://dx.doi.org/10.3390/ijms13010477
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author Frías-Lasserre, Daniel
author_facet Frías-Lasserre, Daniel
author_sort Frías-Lasserre, Daniel
collection PubMed
description The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and genes. ncRNAs are also becoming central for understanding gene expression and silencing. Indeed, before the discovery of ncRNAs, proteins were viewed as the major molecules in the regulation of gene expression and gene silencing; however, recent findings suggest that ncRNA also plays an important role in gene expression. Reverse transcription of RNA viruses and their integration into the genome of eukaryotes and also their relationship with the ncRNA suggest that their origin is basal in genome evolution, and also probably constitute the first mechanism of gene regulation. I am to review the different roles of ncRNAs in the framework of gene evolution, as well as the importance of ncRNAs and viruses in the epigenesis and in the non-Mendelian model of heredity and evolution.
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spelling pubmed-32696992012-02-06 Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity Frías-Lasserre, Daniel Int J Mol Sci Review The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and genes. ncRNAs are also becoming central for understanding gene expression and silencing. Indeed, before the discovery of ncRNAs, proteins were viewed as the major molecules in the regulation of gene expression and gene silencing; however, recent findings suggest that ncRNA also plays an important role in gene expression. Reverse transcription of RNA viruses and their integration into the genome of eukaryotes and also their relationship with the ncRNA suggest that their origin is basal in genome evolution, and also probably constitute the first mechanism of gene regulation. I am to review the different roles of ncRNAs in the framework of gene evolution, as well as the importance of ncRNAs and viruses in the epigenesis and in the non-Mendelian model of heredity and evolution. Molecular Diversity Preservation International (MDPI) 2012-01-04 /pmc/articles/PMC3269699/ /pubmed/22312265 http://dx.doi.org/10.3390/ijms13010477 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Frías-Lasserre, Daniel
Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
title Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
title_full Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
title_fullStr Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
title_full_unstemmed Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
title_short Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
title_sort non coding rnas and viruses in the framework of the phylogeny of the genes, epigenesis and heredity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269699/
https://www.ncbi.nlm.nih.gov/pubmed/22312265
http://dx.doi.org/10.3390/ijms13010477
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