Cargando…

Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism

Obesity, a chronic metabolic disorder, is characterized by enlarged fat mass and dysregulation of lipid metabolism. The medicinal plant, Boesenbergia pandurata (Roxb.) Schltr., has been reported to possess anti-oxidative and anti-inflammatory properties; however, its anti-obesity activity is unexplo...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Dae-Young, Kim, Myung-Suk, Sa, Bo-Kyung, Kim, Mi-Bo, Hwang, Jae-Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269733/
https://www.ncbi.nlm.nih.gov/pubmed/22312299
http://dx.doi.org/10.3390/ijms13010994
_version_ 1782222503627718656
author Kim, Dae-Young
Kim, Myung-Suk
Sa, Bo-Kyung
Kim, Mi-Bo
Hwang, Jae-Kwan
author_facet Kim, Dae-Young
Kim, Myung-Suk
Sa, Bo-Kyung
Kim, Mi-Bo
Hwang, Jae-Kwan
author_sort Kim, Dae-Young
collection PubMed
description Obesity, a chronic metabolic disorder, is characterized by enlarged fat mass and dysregulation of lipid metabolism. The medicinal plant, Boesenbergia pandurata (Roxb.) Schltr., has been reported to possess anti-oxidative and anti-inflammatory properties; however, its anti-obesity activity is unexplored. The present study was conducted to determine whether B. pandurata extract (BPE), prepared from its rhizome parts, attenuated high-fat diet (HFD)-induced obesity in C57BL/6J mice. The molecular mechanism was investigated in 3T3-L1 adipocytes and HepG2 human hepatoma cells. BPE treatment decreased triglyceride accumulation in both 3T3-L1 adipocytes and HepG2 hepatocytes by activating AMP-activated protein kinase (AMPK) signaling and regulating the expression of lipid metabolism-related proteins. In the animal model, oral administration of BPE (200 mg/kg/day for 8 weeks) significantly reduced HFD-induced body weight gain without altering the amount of food intake. In addition, elevated serum levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides were suppressed by BPE administration. Fat pad masses were reduced in BPE-treated mice, as evidenced by reduced adipocyte size. Furthermore, BPE protected against the development of nonalcoholic fatty liver by decreasing hepatic triglyceride accumulation. BPE also activated AMPK signaling and altered the expression of lipid metabolism-related proteins in white adipose tissue and liver. Taken together, these findings indicate that BPE attenuates HFD-induced obesity by activating AMPK and regulating lipid metabolism, suggesting a potent anti-obesity agent.
format Online
Article
Text
id pubmed-3269733
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-32697332012-02-06 Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism Kim, Dae-Young Kim, Myung-Suk Sa, Bo-Kyung Kim, Mi-Bo Hwang, Jae-Kwan Int J Mol Sci Article Obesity, a chronic metabolic disorder, is characterized by enlarged fat mass and dysregulation of lipid metabolism. The medicinal plant, Boesenbergia pandurata (Roxb.) Schltr., has been reported to possess anti-oxidative and anti-inflammatory properties; however, its anti-obesity activity is unexplored. The present study was conducted to determine whether B. pandurata extract (BPE), prepared from its rhizome parts, attenuated high-fat diet (HFD)-induced obesity in C57BL/6J mice. The molecular mechanism was investigated in 3T3-L1 adipocytes and HepG2 human hepatoma cells. BPE treatment decreased triglyceride accumulation in both 3T3-L1 adipocytes and HepG2 hepatocytes by activating AMP-activated protein kinase (AMPK) signaling and regulating the expression of lipid metabolism-related proteins. In the animal model, oral administration of BPE (200 mg/kg/day for 8 weeks) significantly reduced HFD-induced body weight gain without altering the amount of food intake. In addition, elevated serum levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides were suppressed by BPE administration. Fat pad masses were reduced in BPE-treated mice, as evidenced by reduced adipocyte size. Furthermore, BPE protected against the development of nonalcoholic fatty liver by decreasing hepatic triglyceride accumulation. BPE also activated AMPK signaling and altered the expression of lipid metabolism-related proteins in white adipose tissue and liver. Taken together, these findings indicate that BPE attenuates HFD-induced obesity by activating AMPK and regulating lipid metabolism, suggesting a potent anti-obesity agent. Molecular Diversity Preservation International (MDPI) 2012-01-17 /pmc/articles/PMC3269733/ /pubmed/22312299 http://dx.doi.org/10.3390/ijms13010994 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kim, Dae-Young
Kim, Myung-Suk
Sa, Bo-Kyung
Kim, Mi-Bo
Hwang, Jae-Kwan
Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism
title Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism
title_full Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism
title_fullStr Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism
title_full_unstemmed Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism
title_short Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism
title_sort boesenbergia pandurata attenuates diet-induced obesity by activating amp-activated protein kinase and regulating lipid metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269733/
https://www.ncbi.nlm.nih.gov/pubmed/22312299
http://dx.doi.org/10.3390/ijms13010994
work_keys_str_mv AT kimdaeyoung boesenbergiapandurataattenuatesdietinducedobesitybyactivatingampactivatedproteinkinaseandregulatinglipidmetabolism
AT kimmyungsuk boesenbergiapandurataattenuatesdietinducedobesitybyactivatingampactivatedproteinkinaseandregulatinglipidmetabolism
AT sabokyung boesenbergiapandurataattenuatesdietinducedobesitybyactivatingampactivatedproteinkinaseandregulatinglipidmetabolism
AT kimmibo boesenbergiapandurataattenuatesdietinducedobesitybyactivatingampactivatedproteinkinaseandregulatinglipidmetabolism
AT hwangjaekwan boesenbergiapandurataattenuatesdietinducedobesitybyactivatingampactivatedproteinkinaseandregulatinglipidmetabolism