High-Dimensional Descriptor Selection and Computational QSAR Modeling for Antitumor Activity of ARC-111 Analogues Based on Support Vector Regression (SVR)

To design ARC-111 analogues with improved efficiency, we constructed the QSAR of 22 ARC-111 analogues with RPMI8402 tumor cells. First, the optimized support vector regression (SVR) model based on the literature descriptors and the worst descriptor elimination multi-roundly (WDEM) method had similar...

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Detalles Bibliográficos
Autores principales: Zhou, Wei, Dai, Zhijun, Chen, Yuan, Wang, Haiyan, Yuan, Zheming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269744/
https://www.ncbi.nlm.nih.gov/pubmed/22312310
http://dx.doi.org/10.3390/ijms13011161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269744/
https://www.ncbi.nlm.nih.gov/pubmed/22312310
http://dx.doi.org/10.3390/ijms13011161

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