Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1

The I(Ks) potassium channel, critical to control of heart electrical activity, requires assembly of α (KCNQ1) and β (KCNE1) subunits. Inherited mutations in either I(Ks) channel subunit are associated with cardiac arrhythmia syndromes. Two mutations (S140G and V141M) that cause familial atrial fibri...

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Detalles Bibliográficos
Autores principales: Chan, Priscilla J., Osteen, Jeremiah D., Xiong, Dazhi, Bohnen, Michael S., Doshi, Darshan, Sampson, Kevin J., Marx, Steven O., Karlin, Arthur, Kass, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269792/
https://www.ncbi.nlm.nih.gov/pubmed/22250012
http://dx.doi.org/10.1085/jgp.201110672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269792/
https://www.ncbi.nlm.nih.gov/pubmed/22250012
http://dx.doi.org/10.1085/jgp.201110672

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