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Restoration of dystrophin expression using the Sleeping Beauty transposon

The Sleeping beauty (SB) system is a non-viral DNA based vector that has been used to stably integrate therapeutic genes into disease models. Here we report the SB system is capable of stably integrating the ΔR4-R23/CTΔ micro-dystrophin gene into a conditionally immortal dystrophin deficient muscle...

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Detalles Bibliográficos
Autores principales:	Muses, Sofia, Morgan, Jennifer E, Wells, Dominic J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Muscular Dystrophy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269885/ https://www.ncbi.nlm.nih.gov/pubmed/22318674 http://dx.doi.org/10.1371/currents.RRN1296

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