Cargando…

5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis

BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments. Identifying novel drug targets for this indication may open the way for new treatment strategies. Comparison of gene expressio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kapp, Friedrich G, Sommer, Anette, Kiefer, Thomas, Dölken, Gottfried, Haendler, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269976/ https://www.ncbi.nlm.nih.gov/pubmed/22257483 http://dx.doi.org/10.1186/1475-2867-12-1

Ejemplares similares

Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency
por: Marzuki, Nanis S., et al.
Publicado: (2019)

The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population
por: Choi, Se Young, et al.
Publicado: (2015)

A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland
por: Mononen, N, et al.
Publicado: (2001)

Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2
por: Khantham, Chiranan, et al.
Publicado: (2021)

Steroid 5 alpha-reductase 3 (SRD5A3) promotes tumor growth and predicts poor survival of human hepatocellular carcinoma (HCC)
por: Mai, Qicong, et al.
Publicado: (2020)

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism
por: Han, Yufei, et al.
Publicado: (2021)

Identification of three novel SRD5A2 mutations in Chinese patients with 5α-reductase 2 deficiency
por: Cheng, Tong, et al.
Publicado: (2019)

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis
por: Nie, Zi-Yuan, et al.
Publicado: (2020)

Polymorphisms of HPC2/ELAC2 and SRD5A2 (5α-Reductase Type II) Genes in Prostate Cancer
por: İzmirli, M, et al.
Publicado: (2011)

Evidence for an Association between the SRD5A2 (Type II Steroid 5α-Reductase) Locus and Prostate Cancer in Italian Patients
por: Margiotti, K., et al.
Publicado: (2000)

Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur
por: Agarwal, Deepak, et al.
Publicado: (2023)

Try235Phe homozygous mutation of the steroid 5-a reductase type 2 (SRD5A2) gene in a Turkish patient
por: Parlak, Mesut, et al.
Publicado: (2014)

MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF
por: Wang, Zhenlei, et al.
Publicado: (2015)

HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression
por: Liu, Yan, et al.
Publicado: (2021)

Genotype–Phenotype Correlation Analysis and Identification of a Novel SRD5A2 Mutation in Four Unrelated Chinese Patients with 5α-Reductase Deficiency
por: Gui, Ting, et al.
Publicado: (2022)

The Genotype-Phenotype Correlation in Human 5α-Reductase Type 2 Deficiency: Classified and Analyzed from a SRD5A2 Structural Perspective
por: Seo, Jieun, et al.
Publicado: (2023)

Molecular Analysis of the SRD5A1 and SRD5A2 Genes in Patients with Benign Prostatic Hyperplasia with Regard to Metabolic Parameters and Selected Hormone Levels
por: Rył, Aleksandra, et al.
Publicado: (2017)

Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis
por: Liu, Wai Nam, et al.
Publicado: (2015)

CircSMYD4 regulates proliferation, migration and apoptosis of hepatocellular carcinoma cells by sponging miR-584-5p
por: Zhang, Yanhe, et al.
Publicado: (2020)

The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
por: Mao, Cheng-Gang, et al.
Publicado: (2020)

GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma
por: Zhang, Wang, et al.
Publicado: (2021)

MCM3AP-AS1/miR-876-5p/WNT5A axis regulates the proliferation of prostate cancer cells
por: Wu, Jie, et al.
Publicado: (2020)

Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
por: Sun, Qiqing, et al.
Publicado: (2019)

Role of CD5L and SRD5A2 as Prognostic Biomarkers for Hepatocellular Carcinoma
por: Luo, Yunxiu, et al.
Publicado: (2021)

Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis
por: Shi, Ming-Der, et al.
Publicado: (2015)

Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line
por: Li, Jin, et al.
Publicado: (2018)

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis
por: Li, Wei, et al.
Publicado: (2022)

miR-129-5p inhibits clear cell renal cell carcinoma cell proliferation, migration and invasion by targeting SPN
por: Gao, Bin, et al.
Publicado: (2021)

Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma
por: Wang, Jian-Xing, et al.
Publicado: (2020)

THU183 The Genotype-phenotype Correlation In Human 5α-reductase Type 2 Deficiency: Classified And Analysed From A SRD5A2 Structural Perspective
por: Kwon, Ahreum, et al.
Publicado: (2023)

MIAT inhibits proliferation of cervical cancer cells through regulating miR-150-5p
por: Liu, Yanbin, et al.
Publicado: (2020)

β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation
por: Wang, Dongping, et al.
Publicado: (2019)

Adult phenotype and further phenotypic variability in SRD5A3-CDG
por: Kara, Bülent, et al.
Publicado: (2014)

Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway
por: Liu, Xiaowen, et al.
Publicado: (2019)

PTBP3 regulates proliferation of lung squamous cell carcinoma cells via CDC25A‐mediated cell cycle progression
por: Chen, Yingji, et al.
Publicado: (2022)

MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma
por: Zhang, Jun-feng, et al.
Publicado: (2018)

Bursopentin (BP5) induces G1 phase cell cycle arrest and endoplasmic reticulum stress/mitochondria-mediated caspase-dependent apoptosis in human colon cancer HCT116 cells
por: Li, Jing, et al.
Publicado: (2019)

Kaposi’s sarcoma-associated herpesvirus infection promotes proliferation of SH-SY5Y cells by the Notch signaling pathway
por: Cao, Dongdong, et al.
Publicado: (2021)

CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis
por: Qi, Liqiang, et al.
Publicado: (2021)

5-alpha-reductase and the development of the human prostate
por: Radmayr, C., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_2nr5p1esficq5eeqrn2g1h5j23