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Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system

The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. The aim of the present study was to replicate and...

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Autores principales: Gruber, Oliver, Hasan, Alkomiet, Scherk, Harald, Wobrock, Thomas, Schneider-Axmann, Thomas, Ekawardhani, Savira, Schmitt, Andrea, Backens, Martin, Reith, Wolfgang, Meyer, Jobst, Falkai, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270260/
https://www.ncbi.nlm.nih.gov/pubmed/21509595
http://dx.doi.org/10.1007/s00406-011-0214-6
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author Gruber, Oliver
Hasan, Alkomiet
Scherk, Harald
Wobrock, Thomas
Schneider-Axmann, Thomas
Ekawardhani, Savira
Schmitt, Andrea
Backens, Martin
Reith, Wolfgang
Meyer, Jobst
Falkai, Peter
author_facet Gruber, Oliver
Hasan, Alkomiet
Scherk, Harald
Wobrock, Thomas
Schneider-Axmann, Thomas
Ekawardhani, Savira
Schmitt, Andrea
Backens, Martin
Reith, Wolfgang
Meyer, Jobst
Falkai, Peter
author_sort Gruber, Oliver
collection PubMed
description The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. The aim of the present study was to replicate and to extend prior findings of BDNF val66met genotype effects on hippocampal volume and N-acetyl aspartate (NAA) levels. Hundred and fifty-eight caucasians (66 schizophrenic, 45 bipolar, and 47 healthy subjects; 105 subjects underwent MRI and 103 MRS scanning) participated in the study and were genotyped with regard to the val66met polymorphism (rs6265) of the BDNF gene. Hippocampal volumes were determined using structural magnetic resonance imaging (MRI), and measures of biochemical markers were taken using proton magnetic resonance spectroscopy ((1)H-MRS) in the hippocampus and other brain regions. Verbal memory was assessed as a behavioral index of hippocampal function. BDNF genotype did not impact hippocampal volumes. Significant genotype effects were found on metabolic markers specifically in the left hippocampus. In particular, homozygous carriers of the met-allele exhibited significantly lower NAA/Cre and (Glu + Gln)/Cre metabolic ratios compared with val/val homozygotes, independently of psychiatric diagnoses. BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus.
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spelling pubmed-32702602012-02-16 Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system Gruber, Oliver Hasan, Alkomiet Scherk, Harald Wobrock, Thomas Schneider-Axmann, Thomas Ekawardhani, Savira Schmitt, Andrea Backens, Martin Reith, Wolfgang Meyer, Jobst Falkai, Peter Eur Arch Psychiatry Clin Neurosci Original Paper The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. The aim of the present study was to replicate and to extend prior findings of BDNF val66met genotype effects on hippocampal volume and N-acetyl aspartate (NAA) levels. Hundred and fifty-eight caucasians (66 schizophrenic, 45 bipolar, and 47 healthy subjects; 105 subjects underwent MRI and 103 MRS scanning) participated in the study and were genotyped with regard to the val66met polymorphism (rs6265) of the BDNF gene. Hippocampal volumes were determined using structural magnetic resonance imaging (MRI), and measures of biochemical markers were taken using proton magnetic resonance spectroscopy ((1)H-MRS) in the hippocampus and other brain regions. Verbal memory was assessed as a behavioral index of hippocampal function. BDNF genotype did not impact hippocampal volumes. Significant genotype effects were found on metabolic markers specifically in the left hippocampus. In particular, homozygous carriers of the met-allele exhibited significantly lower NAA/Cre and (Glu + Gln)/Cre metabolic ratios compared with val/val homozygotes, independently of psychiatric diagnoses. BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus. Springer-Verlag 2011-04-21 2012 /pmc/articles/PMC3270260/ /pubmed/21509595 http://dx.doi.org/10.1007/s00406-011-0214-6 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Paper
Gruber, Oliver
Hasan, Alkomiet
Scherk, Harald
Wobrock, Thomas
Schneider-Axmann, Thomas
Ekawardhani, Savira
Schmitt, Andrea
Backens, Martin
Reith, Wolfgang
Meyer, Jobst
Falkai, Peter
Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
title Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
title_full Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
title_fullStr Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
title_full_unstemmed Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
title_short Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
title_sort association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270260/
https://www.ncbi.nlm.nih.gov/pubmed/21509595
http://dx.doi.org/10.1007/s00406-011-0214-6
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