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Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients
BACKGROUND AND AIMS: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10and IL-17A serum levels in patients suffering from OBI. MATERIAL AN...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270342/ https://www.ncbi.nlm.nih.gov/pubmed/22308123 |
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author | Arababadi, Mohammad Kazemi Pourfathollah, Ali Akbar Jafarzadeh, Abdollah Hassanshahi, Gholamhossein |
author_facet | Arababadi, Mohammad Kazemi Pourfathollah, Ali Akbar Jafarzadeh, Abdollah Hassanshahi, Gholamhossein |
author_sort | Arababadi, Mohammad Kazemi |
collection | PubMed |
description | BACKGROUND AND AIMS: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10and IL-17A serum levels in patients suffering from OBI. MATERIAL AND METHODS: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis Bsurface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). HBV-DNA positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA. RESULTS: The results demonstrated that, 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1%) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001). CONCLUSIONS: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed. |
format | Online Article Text |
id | pubmed-3270342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-32703422012-02-03 Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients Arababadi, Mohammad Kazemi Pourfathollah, Ali Akbar Jafarzadeh, Abdollah Hassanshahi, Gholamhossein Hepat Mon Original Article BACKGROUND AND AIMS: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10and IL-17A serum levels in patients suffering from OBI. MATERIAL AND METHODS: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis Bsurface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). HBV-DNA positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA. RESULTS: The results demonstrated that, 352 (9.5%) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1%) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001). CONCLUSIONS: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed. Kowsar 2010 2010-03-01 /pmc/articles/PMC3270342/ /pubmed/22308123 Text en Copyright © 2011, Kowsar M.P. Co. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Arababadi, Mohammad Kazemi Pourfathollah, Ali Akbar Jafarzadeh, Abdollah Hassanshahi, Gholamhossein Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients |
title | Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients |
title_full | Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients |
title_fullStr | Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients |
title_full_unstemmed | Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients |
title_short | Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients |
title_sort | serum levels of il-10 and il-17a in occult hbv-infected south-east iranian patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270342/ https://www.ncbi.nlm.nih.gov/pubmed/22308123 |
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