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Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
Topoisomerases I are ubiquitous enzymes that control DNA topology within the cell. They are the unique target of the antitumor drug camptothecin that selectively recognizes the DNA-topoisomerase covalent complex and reversibly stabilizes it. The biochemical and structural-dynamical properties of the...
Autores principales: | D'Annessa, Ilda, Tesauro, Cinzia, Fiorani, Paola, Chillemi, Giovanni, Castelli, Silvia, Vassallo, Oscar, Capranico, Giovanni, Desideri, Alessandro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270393/ https://www.ncbi.nlm.nih.gov/pubmed/22315664 http://dx.doi.org/10.1155/2012/206083 |
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