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B-Cell Response during Protozoan Parasite Infections

In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In ad...

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Detalles Bibliográficos
Autores principales: Amezcua Vesely, María C., Bermejo, Daniela A., Montes, Carolina L., Acosta-Rodríguez, Eva V., Gruppi, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270435/
https://www.ncbi.nlm.nih.gov/pubmed/22315659
http://dx.doi.org/10.1155/2012/362131
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author Amezcua Vesely, María C.
Bermejo, Daniela A.
Montes, Carolina L.
Acosta-Rodríguez, Eva V.
Gruppi, Adriana
author_facet Amezcua Vesely, María C.
Bermejo, Daniela A.
Montes, Carolina L.
Acosta-Rodríguez, Eva V.
Gruppi, Adriana
author_sort Amezcua Vesely, María C.
collection PubMed
description In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections.
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spelling pubmed-32704352012-02-07 B-Cell Response during Protozoan Parasite Infections Amezcua Vesely, María C. Bermejo, Daniela A. Montes, Carolina L. Acosta-Rodríguez, Eva V. Gruppi, Adriana J Parasitol Res Review Article In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections. Hindawi Publishing Corporation 2012 2012-01-23 /pmc/articles/PMC3270435/ /pubmed/22315659 http://dx.doi.org/10.1155/2012/362131 Text en Copyright © 2012 María C. Amezcua Vesely et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Amezcua Vesely, María C.
Bermejo, Daniela A.
Montes, Carolina L.
Acosta-Rodríguez, Eva V.
Gruppi, Adriana
B-Cell Response during Protozoan Parasite Infections
title B-Cell Response during Protozoan Parasite Infections
title_full B-Cell Response during Protozoan Parasite Infections
title_fullStr B-Cell Response during Protozoan Parasite Infections
title_full_unstemmed B-Cell Response during Protozoan Parasite Infections
title_short B-Cell Response during Protozoan Parasite Infections
title_sort b-cell response during protozoan parasite infections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270435/
https://www.ncbi.nlm.nih.gov/pubmed/22315659
http://dx.doi.org/10.1155/2012/362131
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