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B-Cell Response during Protozoan Parasite Infections
In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In ad...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270435/ https://www.ncbi.nlm.nih.gov/pubmed/22315659 http://dx.doi.org/10.1155/2012/362131 |
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author | Amezcua Vesely, María C. Bermejo, Daniela A. Montes, Carolina L. Acosta-Rodríguez, Eva V. Gruppi, Adriana |
author_facet | Amezcua Vesely, María C. Bermejo, Daniela A. Montes, Carolina L. Acosta-Rodríguez, Eva V. Gruppi, Adriana |
author_sort | Amezcua Vesely, María C. |
collection | PubMed |
description | In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections. |
format | Online Article Text |
id | pubmed-3270435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32704352012-02-07 B-Cell Response during Protozoan Parasite Infections Amezcua Vesely, María C. Bermejo, Daniela A. Montes, Carolina L. Acosta-Rodríguez, Eva V. Gruppi, Adriana J Parasitol Res Review Article In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections. Hindawi Publishing Corporation 2012 2012-01-23 /pmc/articles/PMC3270435/ /pubmed/22315659 http://dx.doi.org/10.1155/2012/362131 Text en Copyright © 2012 María C. Amezcua Vesely et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Amezcua Vesely, María C. Bermejo, Daniela A. Montes, Carolina L. Acosta-Rodríguez, Eva V. Gruppi, Adriana B-Cell Response during Protozoan Parasite Infections |
title | B-Cell Response during Protozoan Parasite Infections |
title_full | B-Cell Response during Protozoan Parasite Infections |
title_fullStr | B-Cell Response during Protozoan Parasite Infections |
title_full_unstemmed | B-Cell Response during Protozoan Parasite Infections |
title_short | B-Cell Response during Protozoan Parasite Infections |
title_sort | b-cell response during protozoan parasite infections |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270435/ https://www.ncbi.nlm.nih.gov/pubmed/22315659 http://dx.doi.org/10.1155/2012/362131 |
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