Cargando…

Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats

A lipid-based physiologically based toxicokinetic (PBTK) model has been developed for a mixture of six polychlorinated biphenyls (PCBs) in rats. The aim of this study was to apply population Bayesian analysis to a lipid PBTK model, while incorporating an internal exposure-response model linking enzy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasso, Alan F., Georgopoulos, Panos G., Isukapalli, Sastry S., Krishnan, Kannan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270437/ https://www.ncbi.nlm.nih.gov/pubmed/22315591 http://dx.doi.org/10.1155/2012/895391

Ejemplares similares

A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals
por: Sasso, Alan F, et al.
Publicado: (2010)

Physiologically-Based Toxicokinetic Modeling of Zearalenone and Its Metabolites: Application to the Jersey Girl Study
por: Mukherjee, Dwaipayan, et al.
Publicado: (2014)

Physiological modeling of toxicokinetic interactions: implications for mixture risk assessment.
por: Haddad, S, et al.
Publicado: (1998)

Physiology-based toxicokinetic modelling of aluminium in rat and man
por: Hethey, Christoph, et al.
Publicado: (2021)

Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior
por: Stamatelos, Spyros K, et al.
Publicado: (2011)

Mixture prioritization and testing: the importance of toxicokinetics
por: Braeuning, Albert, et al.
Publicado: (2021)

ebTrack: an environmental bioinformatics system built upon ArrayTrack™
por: Chen, Minjun, et al.
Publicado: (2009)

Developing confidence in risk assessments based on physiological toxicokinetic models.
por: Kohn, M C
Publicado: (1996)

The Application of a Physiologically Based Toxicokinetic Model in Health Risk Assessment
por: Chen, Mengting, et al.
Publicado: (2023)

Toxicokinetic Modeling of the Transfer of Non-Dioxin-like Polychlorinated Biphenyls (ndl-PCBs) from Feed and Soil into Laying Hens and Their Eggs
por: Savvateeva, Daria, et al.
Publicado: (2022)

Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model
por: Tonnelier, Arnaud, et al.
Publicado: (2011)

Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits
por: Mavroudis, Panteleimon D., et al.
Publicado: (2018)

Maternal Transfer and Long-Term Population Effects of PCBs in Baltic Grey Seals Using a New Toxicokinetic–Toxicodynamic Population Model
por: Mauritsson, Karl, et al.
Publicado: (2022)

Embryotoxicity and Toxicokinetics of the Antimalarial Artesunate in Rats
por: Chung, Moon-Koo, et al.
Publicado: (2013)

Using National and Local Extant Data to Characterize Environmental Exposures in the National Children’s Study: Queens County, New York
por: Lioy, Paul J., et al.
Publicado: (2009)

Understanding the Multiple Effects of PCBs on Lipid Metabolism
por: Shan, Qiuli, et al.
Publicado: (2020)

PCBs Are Endocrine Disruptors: Mixture Affects Reproductive Development in Female Mice
por: McGovern, Victoria
Publicado: (2006)

Physiologically based pharmacokinetic analyses of simple mixtures.
por: Krishnan, K, et al.
Publicado: (1994)

Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment: Three Case Studies
por: Mielke, Hans, et al.
Publicado: (2012)

Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments
por: Cohen Hubal, Elaine A., et al.
Publicado: (2018)

Toxicokinetics of Kava
por: Rowe, Anthony, et al.
Publicado: (2011)

Mechanistic Middle-Out Physiologically Based Toxicokinetic Modeling of Transporter-Dependent Disposition of Perfluorooctanoic Acid in Humans
por: Lin, Jieying, et al.
Publicado: (2023)

Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats
por: Zhao, Lijuan, et al.
Publicado: (2021)

Scaling basic toxicokinetic parameters from rat to man.
por: Bachmann, K, et al.
Publicado: (1996)

Negligible Toxicokinetic Differences of Glyphosate by Different Vehicles in Rats
por: Kim, Yu-Jin, et al.
Publicado: (2023)

Toxicokinetics of bone lead.
por: Rabinowitz, M B
Publicado: (1991)

Population toxicokinetics of benzene.
por: Bois, F Y, et al.
Publicado: (1996)

Toxicokinetics in Risk Evaluations
por: Punt, Ans
Publicado: (2018)

Standard Reference Materials (SRMs) for the Calibration and Validation of Analytical Methods for PCBs (as Aroclor Mixtures)
por: Poster, Dianne L., et al.
Publicado: (2004)

Perspective on PCBs
Publicado: (1972)

Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches
por: Rowland, Michael A., et al.
Publicado: (2017)

Health status and PCBs in blood of workers exposed to PCBs and of their children.
por: Hara, I
Publicado: (1985)

Physiological modeling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures.
por: Krishnan, Kannan, et al.
Publicado: (2002)

Toxicokinetics of 11 Gelsemium Alkaloids in Rats by UPLC-MS/MS
por: Shen, Xiuwei, et al.
Publicado: (2020)

Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs
por: Li, Xiaobo, et al.
Publicado: (2021)

Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats
por: Caetano, Érika Leão Ajala, et al.
Publicado: (2023)

Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics
por: Ye, Jun, et al.
Publicado: (2022)

Physiologically based toxicokinetic modeling of 1,3-butadiene lung metabolism in mice becomes more important at low doses.
por: Evelo, C T, et al.
Publicado: (1993)

Effects of PCBs and related compounds on hepatocarcinogenesis in rats and mice.
por: Sleight, S
Publicado: (1985)

The biological speciation and toxicokinetics of aluminum.
por: DeVoto, E, et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_3i411l944dm8lfl774l86rkq8e