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Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts

The aim of this study is pharmacochemistry of Iranian flora Artemisia sieberi and its antimalarial effects on Plasmodium berghei in vivo. This is the first application of A. sieberi for treatment of murine malaria. A. sieberi were collected at flowering stage from the Khorassan and Semnan provinces...

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Autores principales: Nahrevanian, Hossein, Sheykhkanlooye Milan, Bayram, Kazemi, Masoud, Hajhosseini, Reza, Soleymani Mashhadi, Soudeh, Nahrevanian, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270465/
https://www.ncbi.nlm.nih.gov/pubmed/22315701
http://dx.doi.org/10.1155/2012/727032
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author Nahrevanian, Hossein
Sheykhkanlooye Milan, Bayram
Kazemi, Masoud
Hajhosseini, Reza
Soleymani Mashhadi, Soudeh
Nahrevanian, Shahab
author_facet Nahrevanian, Hossein
Sheykhkanlooye Milan, Bayram
Kazemi, Masoud
Hajhosseini, Reza
Soleymani Mashhadi, Soudeh
Nahrevanian, Shahab
author_sort Nahrevanian, Hossein
collection PubMed
description The aim of this study is pharmacochemistry of Iranian flora Artemisia sieberi and its antimalarial effects on Plasmodium berghei in vivo. This is the first application of A. sieberi for treatment of murine malaria. A. sieberi were collected at flowering stage from the Khorassan and Semnan provinces of Iran; the aerial parts were air-dried at room temperature and then powdered. The powder was macerated in methanol, filtered with Bokhner hopper and solvent was separated in rotary evaporator. Total herbal extract was subsequently processed for ether and chloroform extracts preparation. The toxicity of herbal extract was assessed on naive NMRI mice with high, average and low doses; then pathophysiological signs were assessed. Finally, the antimalarial efficacy was investigated on two groups of Plasmodium berghei infected mice. Percentage of parasitaemia and pathophysiology were also evaluated. The results of this assessment showed no toxicity even by high concentration of herbal extract. A significant reduction in percentage of parasitaemia was observed; no alterations of hepatosplenomegaly and body weight were indicated in study group. A. sieberi extracts showed antimalarial effects against murine malaria with some efficacies on reducing pathophysiology. However, there is requirement to find the major component of this herbal extract by further studies.
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spelling pubmed-32704652012-02-07 Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts Nahrevanian, Hossein Sheykhkanlooye Milan, Bayram Kazemi, Masoud Hajhosseini, Reza Soleymani Mashhadi, Soudeh Nahrevanian, Shahab Malar Res Treat Research Article The aim of this study is pharmacochemistry of Iranian flora Artemisia sieberi and its antimalarial effects on Plasmodium berghei in vivo. This is the first application of A. sieberi for treatment of murine malaria. A. sieberi were collected at flowering stage from the Khorassan and Semnan provinces of Iran; the aerial parts were air-dried at room temperature and then powdered. The powder was macerated in methanol, filtered with Bokhner hopper and solvent was separated in rotary evaporator. Total herbal extract was subsequently processed for ether and chloroform extracts preparation. The toxicity of herbal extract was assessed on naive NMRI mice with high, average and low doses; then pathophysiological signs were assessed. Finally, the antimalarial efficacy was investigated on two groups of Plasmodium berghei infected mice. Percentage of parasitaemia and pathophysiology were also evaluated. The results of this assessment showed no toxicity even by high concentration of herbal extract. A significant reduction in percentage of parasitaemia was observed; no alterations of hepatosplenomegaly and body weight were indicated in study group. A. sieberi extracts showed antimalarial effects against murine malaria with some efficacies on reducing pathophysiology. However, there is requirement to find the major component of this herbal extract by further studies. Hindawi Publishing Corporation 2012 2012-01-23 /pmc/articles/PMC3270465/ /pubmed/22315701 http://dx.doi.org/10.1155/2012/727032 Text en Copyright © 2012 Hossein Nahrevanian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nahrevanian, Hossein
Sheykhkanlooye Milan, Bayram
Kazemi, Masoud
Hajhosseini, Reza
Soleymani Mashhadi, Soudeh
Nahrevanian, Shahab
Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
title Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
title_full Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
title_fullStr Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
title_full_unstemmed Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
title_short Antimalarial Effects of Iranian Flora Artemisia sieberi on Plasmodium berghei In Vivo in Mice and Phytochemistry Analysis of Its Herbal Extracts
title_sort antimalarial effects of iranian flora artemisia sieberi on plasmodium berghei in vivo in mice and phytochemistry analysis of its herbal extracts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270465/
https://www.ncbi.nlm.nih.gov/pubmed/22315701
http://dx.doi.org/10.1155/2012/727032
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