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Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies

Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to t...

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Detalles Bibliográficos
Autores principales: Johnson, Theodore S., Munn, David H., Maria, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270544/
https://www.ncbi.nlm.nih.gov/pubmed/22312408
http://dx.doi.org/10.1155/2012/937253
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author Johnson, Theodore S.
Munn, David H.
Maria, Bernard L.
author_facet Johnson, Theodore S.
Munn, David H.
Maria, Bernard L.
author_sort Johnson, Theodore S.
collection PubMed
description Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to the survival of the tumor. We review the evidence for functional CNS immune privilege and the impact it has on tumor tolerance. In this paper, we place an emphasis on the role of tumor-infiltrating myeloid cells in maintaining stromal and vascular quiescence, and we underscore the importance of indoleamine 2,3-dioxygenase activity as a myeloid-driven tumor tolerance mechanism. Much remains to be discovered regarding the tolerogenic mechanisms by which CNS tumors avoid immune clearance. Thus, it is an open question whether tumor tolerance in the brain is fundamentally different from that of peripheral sites of tumorigenesis or whether it simply stands as a particularly strong example of such tolerance.
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spelling pubmed-32705442012-02-06 Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies Johnson, Theodore S. Munn, David H. Maria, Bernard L. Clin Dev Immunol Review Article Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to the survival of the tumor. We review the evidence for functional CNS immune privilege and the impact it has on tumor tolerance. In this paper, we place an emphasis on the role of tumor-infiltrating myeloid cells in maintaining stromal and vascular quiescence, and we underscore the importance of indoleamine 2,3-dioxygenase activity as a myeloid-driven tumor tolerance mechanism. Much remains to be discovered regarding the tolerogenic mechanisms by which CNS tumors avoid immune clearance. Thus, it is an open question whether tumor tolerance in the brain is fundamentally different from that of peripheral sites of tumorigenesis or whether it simply stands as a particularly strong example of such tolerance. Hindawi Publishing Corporation 2012 2012-01-24 /pmc/articles/PMC3270544/ /pubmed/22312408 http://dx.doi.org/10.1155/2012/937253 Text en Copyright © 2012 Theodore S. Johnson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Johnson, Theodore S.
Munn, David H.
Maria, Bernard L.
Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
title Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
title_full Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
title_fullStr Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
title_full_unstemmed Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
title_short Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
title_sort modulation of tumor tolerance in primary central nervous system malignancies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270544/
https://www.ncbi.nlm.nih.gov/pubmed/22312408
http://dx.doi.org/10.1155/2012/937253
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