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Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects
BACKGROUND: Overweight is associated with an increased cardiovascular risk which is only partially explained by conventional risk factors. The objective of this study was to evaluate lipoprotein(a) [Lp(a)] plasma levels and apolipoprotein(a) [apo(a)] phenotypes in relation to coronary heart disease...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC327094/ https://www.ncbi.nlm.nih.gov/pubmed/14670093 http://dx.doi.org/10.1186/1471-2261-3-12 |
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author | Emanuele, Enzo Peros, Emmanouil Minoretti, Piercarlo Falcone, Colomba D'Angelo, Angela Montagna, Lorenza Geroldi, Diego |
author_facet | Emanuele, Enzo Peros, Emmanouil Minoretti, Piercarlo Falcone, Colomba D'Angelo, Angela Montagna, Lorenza Geroldi, Diego |
author_sort | Emanuele, Enzo |
collection | PubMed |
description | BACKGROUND: Overweight is associated with an increased cardiovascular risk which is only partially explained by conventional risk factors. The objective of this study was to evaluate lipoprotein(a) [Lp(a)] plasma levels and apolipoprotein(a) [apo(a)] phenotypes in relation to coronary heart disease (CHD) in overweight subjects. METHODS: A total of 275 overweight (BMI ≥ 27 kg/m(2)) subjects, of which 155 had experienced a CHD event, 337 normal weight subjects with prior CHD and 103 CHD-free normal weight subjects were enrolled in the study. Lp(a) levels were determined by an ELISA technique and apo(a) isoforms were detected by a high-resolution immunoblotting method. RESULTS: Lp(a) levels were similar in the three study groups. Overweight subjects with CHD had Lp(a) concentrations significantly higher than those without [median (interquartile range): 20 (5–50.3) versus 12.6 (2.6–38.6) mg/dl, P < 0.05]. Furthermore, overweight subjects with CHD showed a higher prevalence of low molecular weight apo(a) isoforms than those without (55.5% versus 40.8%, P < 0.05) and with respect to the control group (55.5% versus 39.8%, P < 0.05). Stepwise regression analysis showed that apo(a) phenotypes, but not Lp(a) levels, entered the model as significant independent predictors of CHD in overweight subjects. CONCLUSIONS: Our data indicate that small-sized apo(a) isoforms are associated with CHD in overweight subjects. The characterization of apo(a) phenotypes might serve as a reliable biomarker to better assess the overall CHD risk of each subject with elevated BMI, leading to more intensive treatment of modifiable cardiovascular risk factors. |
format | Text |
id | pubmed-327094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-3270942004-02-04 Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects Emanuele, Enzo Peros, Emmanouil Minoretti, Piercarlo Falcone, Colomba D'Angelo, Angela Montagna, Lorenza Geroldi, Diego BMC Cardiovasc Disord Research Article BACKGROUND: Overweight is associated with an increased cardiovascular risk which is only partially explained by conventional risk factors. The objective of this study was to evaluate lipoprotein(a) [Lp(a)] plasma levels and apolipoprotein(a) [apo(a)] phenotypes in relation to coronary heart disease (CHD) in overweight subjects. METHODS: A total of 275 overweight (BMI ≥ 27 kg/m(2)) subjects, of which 155 had experienced a CHD event, 337 normal weight subjects with prior CHD and 103 CHD-free normal weight subjects were enrolled in the study. Lp(a) levels were determined by an ELISA technique and apo(a) isoforms were detected by a high-resolution immunoblotting method. RESULTS: Lp(a) levels were similar in the three study groups. Overweight subjects with CHD had Lp(a) concentrations significantly higher than those without [median (interquartile range): 20 (5–50.3) versus 12.6 (2.6–38.6) mg/dl, P < 0.05]. Furthermore, overweight subjects with CHD showed a higher prevalence of low molecular weight apo(a) isoforms than those without (55.5% versus 40.8%, P < 0.05) and with respect to the control group (55.5% versus 39.8%, P < 0.05). Stepwise regression analysis showed that apo(a) phenotypes, but not Lp(a) levels, entered the model as significant independent predictors of CHD in overweight subjects. CONCLUSIONS: Our data indicate that small-sized apo(a) isoforms are associated with CHD in overweight subjects. The characterization of apo(a) phenotypes might serve as a reliable biomarker to better assess the overall CHD risk of each subject with elevated BMI, leading to more intensive treatment of modifiable cardiovascular risk factors. BioMed Central 2003-12-12 /pmc/articles/PMC327094/ /pubmed/14670093 http://dx.doi.org/10.1186/1471-2261-3-12 Text en Copyright © 2003 Emanuele et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Article Emanuele, Enzo Peros, Emmanouil Minoretti, Piercarlo Falcone, Colomba D'Angelo, Angela Montagna, Lorenza Geroldi, Diego Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
title | Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
title_full | Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
title_fullStr | Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
title_full_unstemmed | Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
title_short | Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
title_sort | relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC327094/ https://www.ncbi.nlm.nih.gov/pubmed/14670093 http://dx.doi.org/10.1186/1471-2261-3-12 |
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