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Transforming Growth Factor-β Protein Inversely Regulates in Vivo Differentiation of Interleukin-17 (IL-17)-producing CD4(+) and CD8(+) T Cells

TGF-β is a pleiotropic cytokine that predominantly exerts inhibitory functions in the immune system. Unexpectedly, the in vitro differentiation of both Th17 and Tc17 cells requires TGF-β. However, animals that are impaired in TGF-β signaling (TGF-βRIIDN mice) display multiorgan autoimmune disorders....

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Detalles Bibliográficos
Autores principales:	Dwivedi, Ved Prakash, Tousif, Sultan, Bhattacharya, Debapriya, Prasad, Durbaka Vijay Raghva, Van Kaer, Luc, Das, Jyoti, Das, Gobardhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270951/ https://www.ncbi.nlm.nih.gov/pubmed/22170065 http://dx.doi.org/10.1074/jbc.C111.327627

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