Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

BACKGROUND: Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is obse...

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Detalles Bibliográficos
Autores principales: Cabeza-Arvelaiz, Yofre, Fleming, Sheila M, Richter, Franziska, Masliah, Eliezer, Chesselet, Marie-Francoise, Schiestl, Robert H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271045/
https://www.ncbi.nlm.nih.gov/pubmed/22165993
http://dx.doi.org/10.1186/1750-1326-6-83

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