A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy

Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3′UTR of HBEGF were predicted using miRWalk algorithm and followed by DNA sequencing in 103 patients diagnosed with mild or severe glomerulop...

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Detalles Bibliográficos
Autores principales: Papagregoriou, Gregory, Erguler, Kamil, Dweep, Harsh, Voskarides, Konstantinos, Koupepidou, Panayiota, Athanasiou, Yiannis, Pierides, Alkis, Gretz, Norbert, Felekkis, Kyriacos N., Deltas, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271095/
https://www.ncbi.nlm.nih.gov/pubmed/22319602
http://dx.doi.org/10.1371/journal.pone.0031021

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