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Serum from Calorie-Restricted Rats Activates Vascular Cell eNOS through Enhanced Insulin Signaling Mediated by Adiponectin

eNOS activation resulting in mitochondrial biogenesis is believed to play a central role in life span extension promoted by calorie restriction (CR). We investigated the mechanism of this activation by treating vascular cells with serum from CR rats and found increased Akt and eNOS phosphorylation,...

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Detalles Bibliográficos
Autores principales:	Cerqueira, Fernanda M., Brandizzi, Laura I., Cunha, Fernanda M., Laurindo, Francisco R. M., Kowaltowski, Alicia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271099/ https://www.ncbi.nlm.nih.gov/pubmed/22319612 http://dx.doi.org/10.1371/journal.pone.0031155

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