STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma

Constitutive activation of STAT3 is a common feature in many solid tumors including non-small cell lung carcinoma (NSCLC). While activation of STAT3 is commonly achieved by somatic mutations to JAK2 in hematologic malignancies, similar mutations are not often found in solid tumors. Previous work has...

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Detalles Bibliográficos
Autores principales: Looyenga, Brendan D., Hutchings, Danielle, Cherni, Irene, Kingsley, Chris, Weiss, Glen J., MacKeigan, Jeffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271110/
https://www.ncbi.nlm.nih.gov/pubmed/22319590
http://dx.doi.org/10.1371/journal.pone.0030820

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