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CYTOCHROME P450 17A1 STRUCTURES WITH PROSTATE CANCER DRUGS ABIRATERONE AND TOK-001
Cytochrome P450 17A1 (P450c17) catalyzes the biosynthesis of androgens in humans(1). Since prostate cancer cells proliferate in response to androgen steroids(2,3), CYP17A1 inhibition is a new strategy to prevent androgen synthesis and treat lethal metastatic castration-resistant prostate cancer(4),...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271139/ https://www.ncbi.nlm.nih.gov/pubmed/22266943 http://dx.doi.org/10.1038/nature10743 |