Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B

Activation of toll-like receptors (TLRs) induces the endoplasmic reticulum (ER) Unfolded Protein Response (UPR) to accommodate essential protein translation(1,2). However, despite increased p-eIF2α, a TLR-TRIF-dependent pathway assures that the cells avoid CHOP induction, apoptosis, and translationa...

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Detalles Bibliográficos
Autores principales: Woo, Connie W., Kutzler, Lydia, Kimball, Scot R., Tabas, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271190/
https://www.ncbi.nlm.nih.gov/pubmed/22231169
http://dx.doi.org/10.1038/ncb2408

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