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EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusio...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271302/ https://www.ncbi.nlm.nih.gov/pubmed/22323876 http://dx.doi.org/10.3346/jkms.2012.27.2.228 |
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author | Jin, Guang Jeon, Hyo-Sung Lee, Eung Bae Kang, Hyo-Gyoung Yoo, Seung Soo Lee, Shin Yup Lee, Jae Hee Cha, Sung Ick Park, Tae In Kim, Chang Ho Jheon, Sang Hoon Park, Jae Yong |
author_facet | Jin, Guang Jeon, Hyo-Sung Lee, Eung Bae Kang, Hyo-Gyoung Yoo, Seung Soo Lee, Shin Yup Lee, Jae Hee Cha, Sung Ick Park, Tae In Kim, Chang Ho Jheon, Sang Hoon Park, Jae Yong |
author_sort | Jin, Guang |
collection | PubMed |
description | A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs. |
format | Online Article Text |
id | pubmed-3271302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-32713022012-02-09 EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer Jin, Guang Jeon, Hyo-Sung Lee, Eung Bae Kang, Hyo-Gyoung Yoo, Seung Soo Lee, Shin Yup Lee, Jae Hee Cha, Sung Ick Park, Tae In Kim, Chang Ho Jheon, Sang Hoon Park, Jae Yong J Korean Med Sci Brief Communication A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs. The Korean Academy of Medical Sciences 2012-02 2012-01-27 /pmc/articles/PMC3271302/ /pubmed/22323876 http://dx.doi.org/10.3346/jkms.2012.27.2.228 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Jin, Guang Jeon, Hyo-Sung Lee, Eung Bae Kang, Hyo-Gyoung Yoo, Seung Soo Lee, Shin Yup Lee, Jae Hee Cha, Sung Ick Park, Tae In Kim, Chang Ho Jheon, Sang Hoon Park, Jae Yong EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer |
title | EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer |
title_full | EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer |
title_fullStr | EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer |
title_full_unstemmed | EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer |
title_short | EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer |
title_sort | eml4-alk fusion gene in korean non-small cell lung cancer |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271302/ https://www.ncbi.nlm.nih.gov/pubmed/22323876 http://dx.doi.org/10.3346/jkms.2012.27.2.228 |
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