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Risk factors of childhood epilepsy in Kerala
BACKGROUND: We aimed to identify the risk factors for epilepsy in children. MATERIALS AND METHODS: This case–control retrospective study was carried out in the pediatric neurology outpatient service of the Trivandrum Medical College. All children (1–12 years) with epilepsy satisfying the selection c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271468/ https://www.ncbi.nlm.nih.gov/pubmed/22346018 http://dx.doi.org/10.4103/0972-2327.91950 |
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author | Attumalil, Thomas Varghese Sundaram, Anil Varghese, Vivek Oommen Vijayakumar, K. Kunju, P. A. Mohammed |
author_facet | Attumalil, Thomas Varghese Sundaram, Anil Varghese, Vivek Oommen Vijayakumar, K. Kunju, P. A. Mohammed |
author_sort | Attumalil, Thomas Varghese |
collection | PubMed |
description | BACKGROUND: We aimed to identify the risk factors for epilepsy in children. MATERIALS AND METHODS: This case–control retrospective study was carried out in the pediatric neurology outpatient service of the Trivandrum Medical College. All children (1–12 years) with epilepsy satisfying the selection criteria were included, after obtaining consent from parents. Those with single seizures or febrile seizures were excluded. Controls were children without epilepsy attending the same hospital. Parents were interviewed and clinical data were obtained from medical records. Statistical analysis included chi-square test, odds ratio (OR), and logistic regression. RESULTS: There were 82 cases and 160 controls whose mean age was 6.9 + 3.6 and 5.2 + 3.1, years respectively. On univariate analysis, family history of epilepsy, prolonged labor, cyanosis at birth, delayed cry after birth, admission to newborn intensive care unit, presence of congenital malformations, neurocutaneous markers, incessant cry in the first week, delayed developmental milestones, meningitis, encephalitis, and head trauma were found to be significant. On logistic regression, family history of epilepsy (OR 4.7), newborn distress (OR 8.6), delayed developmental milestones (OR 12.6), and head trauma (OR 5.8) were found to be significant predictors. Infants who had history of newborn distress are likely to manifest epilepsy before 1 year if they are eventually going to have epilepsy (OR 3.4). CONCLUSION: Modifiable factors such as newborn distress and significant head trauma are significant risk factors for childhood epilepsy. Newborn distress is a risk factor for early-onset (<1 year age) epilepsy. |
format | Online Article Text |
id | pubmed-3271468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32714682012-02-15 Risk factors of childhood epilepsy in Kerala Attumalil, Thomas Varghese Sundaram, Anil Varghese, Vivek Oommen Vijayakumar, K. Kunju, P. A. Mohammed Ann Indian Acad Neurol Short Communication BACKGROUND: We aimed to identify the risk factors for epilepsy in children. MATERIALS AND METHODS: This case–control retrospective study was carried out in the pediatric neurology outpatient service of the Trivandrum Medical College. All children (1–12 years) with epilepsy satisfying the selection criteria were included, after obtaining consent from parents. Those with single seizures or febrile seizures were excluded. Controls were children without epilepsy attending the same hospital. Parents were interviewed and clinical data were obtained from medical records. Statistical analysis included chi-square test, odds ratio (OR), and logistic regression. RESULTS: There were 82 cases and 160 controls whose mean age was 6.9 + 3.6 and 5.2 + 3.1, years respectively. On univariate analysis, family history of epilepsy, prolonged labor, cyanosis at birth, delayed cry after birth, admission to newborn intensive care unit, presence of congenital malformations, neurocutaneous markers, incessant cry in the first week, delayed developmental milestones, meningitis, encephalitis, and head trauma were found to be significant. On logistic regression, family history of epilepsy (OR 4.7), newborn distress (OR 8.6), delayed developmental milestones (OR 12.6), and head trauma (OR 5.8) were found to be significant predictors. Infants who had history of newborn distress are likely to manifest epilepsy before 1 year if they are eventually going to have epilepsy (OR 3.4). CONCLUSION: Modifiable factors such as newborn distress and significant head trauma are significant risk factors for childhood epilepsy. Newborn distress is a risk factor for early-onset (<1 year age) epilepsy. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3271468/ /pubmed/22346018 http://dx.doi.org/10.4103/0972-2327.91950 Text en Copyright: © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Attumalil, Thomas Varghese Sundaram, Anil Varghese, Vivek Oommen Vijayakumar, K. Kunju, P. A. Mohammed Risk factors of childhood epilepsy in Kerala |
title | Risk factors of childhood epilepsy in Kerala |
title_full | Risk factors of childhood epilepsy in Kerala |
title_fullStr | Risk factors of childhood epilepsy in Kerala |
title_full_unstemmed | Risk factors of childhood epilepsy in Kerala |
title_short | Risk factors of childhood epilepsy in Kerala |
title_sort | risk factors of childhood epilepsy in kerala |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271468/ https://www.ncbi.nlm.nih.gov/pubmed/22346018 http://dx.doi.org/10.4103/0972-2327.91950 |
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