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Posterior fossa involvement in a recurrent gliosarcoma
Gliosarcoma (GSM) is a WHO grade 4 tumor and a variant of glioblastoma multiforme with predilection for the temporal lobe. We record, perhaps the first case in literature, of a temporal lobe GSM with recurrence involving the posterior fossa. A 50-year-old man presented to us with headache, vomiting,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271620/ https://www.ncbi.nlm.nih.gov/pubmed/22346196 http://dx.doi.org/10.4103/0976-3147.91944 |
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author | Balasubramaniam, Srikant Tyagi, Devendra K Sawant, Hemant V Epari, Sridhar |
author_facet | Balasubramaniam, Srikant Tyagi, Devendra K Sawant, Hemant V Epari, Sridhar |
author_sort | Balasubramaniam, Srikant |
collection | PubMed |
description | Gliosarcoma (GSM) is a WHO grade 4 tumor and a variant of glioblastoma multiforme with predilection for the temporal lobe. We record, perhaps the first case in literature, of a temporal lobe GSM with recurrence involving the posterior fossa. A 50-year-old man presented to us with headache, vomiting, and lethargy of relatively recent onset. Magnetic resonance imaging revealed a well-circumscribed lesion in the left temporal lobe for which left temporal craniotomy with radical excision of the tumor was performed. Histopathology was suggestive of GSM. He presented to us within a month of the first surgery with a large recurrence involving the temporal lobe. He underwent a second surgery with radical excision of the tumor. Histopathology was confirmatory of GSM. He was administered concomitant chemotherapy and radiotherapy. Within a fortnight of starting adjuvant therapy, the bone flap started bulging and a repeat computed tomography scan revealed a large recurrence extending into the posterior fossa. The patient's relatives refused consent for third surgery and he finally succumbed on postoperative day 21. GSMs are aggressive tumors that have a temporal lobe predilection, but they may present anywhere in the brain. Detailed studies on larger cohort of cases are needed to understand the true nature of these biphasic tumors. |
format | Online Article Text |
id | pubmed-3271620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32716202012-02-15 Posterior fossa involvement in a recurrent gliosarcoma Balasubramaniam, Srikant Tyagi, Devendra K Sawant, Hemant V Epari, Sridhar J Neurosci Rural Pract Case Report Gliosarcoma (GSM) is a WHO grade 4 tumor and a variant of glioblastoma multiforme with predilection for the temporal lobe. We record, perhaps the first case in literature, of a temporal lobe GSM with recurrence involving the posterior fossa. A 50-year-old man presented to us with headache, vomiting, and lethargy of relatively recent onset. Magnetic resonance imaging revealed a well-circumscribed lesion in the left temporal lobe for which left temporal craniotomy with radical excision of the tumor was performed. Histopathology was suggestive of GSM. He presented to us within a month of the first surgery with a large recurrence involving the temporal lobe. He underwent a second surgery with radical excision of the tumor. Histopathology was confirmatory of GSM. He was administered concomitant chemotherapy and radiotherapy. Within a fortnight of starting adjuvant therapy, the bone flap started bulging and a repeat computed tomography scan revealed a large recurrence extending into the posterior fossa. The patient's relatives refused consent for third surgery and he finally succumbed on postoperative day 21. GSMs are aggressive tumors that have a temporal lobe predilection, but they may present anywhere in the brain. Detailed studies on larger cohort of cases are needed to understand the true nature of these biphasic tumors. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3271620/ /pubmed/22346196 http://dx.doi.org/10.4103/0976-3147.91944 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Balasubramaniam, Srikant Tyagi, Devendra K Sawant, Hemant V Epari, Sridhar Posterior fossa involvement in a recurrent gliosarcoma |
title | Posterior fossa involvement in a recurrent gliosarcoma |
title_full | Posterior fossa involvement in a recurrent gliosarcoma |
title_fullStr | Posterior fossa involvement in a recurrent gliosarcoma |
title_full_unstemmed | Posterior fossa involvement in a recurrent gliosarcoma |
title_short | Posterior fossa involvement in a recurrent gliosarcoma |
title_sort | posterior fossa involvement in a recurrent gliosarcoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271620/ https://www.ncbi.nlm.nih.gov/pubmed/22346196 http://dx.doi.org/10.4103/0976-3147.91944 |
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