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Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. PATIENTS AND METHODS: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridizatio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271696/ https://www.ncbi.nlm.nih.gov/pubmed/22249094 http://dx.doi.org/10.4103/1319-3767.91734 |
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author | Swidsinski, Alexander Dörffel, Yvonne Loening-Baucke, Vera Tertychnyy, Alexander Biche-ool, Salbakay Stonogin, Sergei Guo, Yi Sun, Ning-Dong |
author_facet | Swidsinski, Alexander Dörffel, Yvonne Loening-Baucke, Vera Tertychnyy, Alexander Biche-ool, Salbakay Stonogin, Sergei Guo, Yi Sun, Ning-Dong |
author_sort | Swidsinski, Alexander |
collection | PubMed |
description | BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. PATIENTS AND METHODS: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls. RESULTS: Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70–71% and in formalin-fixated material was 30–36%. CONCLUSIONS: Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role. |
format | Online Article Text |
id | pubmed-3271696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32716962012-02-15 Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China Swidsinski, Alexander Dörffel, Yvonne Loening-Baucke, Vera Tertychnyy, Alexander Biche-ool, Salbakay Stonogin, Sergei Guo, Yi Sun, Ning-Dong Saudi J Gastroenterol Original Article BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. PATIENTS AND METHODS: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls. RESULTS: Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70–71% and in formalin-fixated material was 30–36%. CONCLUSIONS: Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3271696/ /pubmed/22249094 http://dx.doi.org/10.4103/1319-3767.91734 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Swidsinski, Alexander Dörffel, Yvonne Loening-Baucke, Vera Tertychnyy, Alexander Biche-ool, Salbakay Stonogin, Sergei Guo, Yi Sun, Ning-Dong Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China |
title | Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China |
title_full | Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China |
title_fullStr | Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China |
title_full_unstemmed | Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China |
title_short | Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China |
title_sort | mucosal invasion by fusobacteria is a common feature of acute appendicitis in germany, russia, and china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271696/ https://www.ncbi.nlm.nih.gov/pubmed/22249094 http://dx.doi.org/10.4103/1319-3767.91734 |
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