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Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China

BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. PATIENTS AND METHODS: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridizatio...

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Autores principales: Swidsinski, Alexander, Dörffel, Yvonne, Loening-Baucke, Vera, Tertychnyy, Alexander, Biche-ool, Salbakay, Stonogin, Sergei, Guo, Yi, Sun, Ning-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271696/
https://www.ncbi.nlm.nih.gov/pubmed/22249094
http://dx.doi.org/10.4103/1319-3767.91734
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author Swidsinski, Alexander
Dörffel, Yvonne
Loening-Baucke, Vera
Tertychnyy, Alexander
Biche-ool, Salbakay
Stonogin, Sergei
Guo, Yi
Sun, Ning-Dong
author_facet Swidsinski, Alexander
Dörffel, Yvonne
Loening-Baucke, Vera
Tertychnyy, Alexander
Biche-ool, Salbakay
Stonogin, Sergei
Guo, Yi
Sun, Ning-Dong
author_sort Swidsinski, Alexander
collection PubMed
description BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. PATIENTS AND METHODS: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls. RESULTS: Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70–71% and in formalin-fixated material was 30–36%. CONCLUSIONS: Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role.
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spelling pubmed-32716962012-02-15 Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China Swidsinski, Alexander Dörffel, Yvonne Loening-Baucke, Vera Tertychnyy, Alexander Biche-ool, Salbakay Stonogin, Sergei Guo, Yi Sun, Ning-Dong Saudi J Gastroenterol Original Article BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis. PATIENTS AND METHODS: Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls. RESULTS: Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70–71% and in formalin-fixated material was 30–36%. CONCLUSIONS: Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3271696/ /pubmed/22249094 http://dx.doi.org/10.4103/1319-3767.91734 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Swidsinski, Alexander
Dörffel, Yvonne
Loening-Baucke, Vera
Tertychnyy, Alexander
Biche-ool, Salbakay
Stonogin, Sergei
Guo, Yi
Sun, Ning-Dong
Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
title Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
title_full Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
title_fullStr Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
title_full_unstemmed Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
title_short Mucosal Invasion by Fusobacteria is a Common Feature of Acute Appendicitis in Germany, Russia, and China
title_sort mucosal invasion by fusobacteria is a common feature of acute appendicitis in germany, russia, and china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271696/
https://www.ncbi.nlm.nih.gov/pubmed/22249094
http://dx.doi.org/10.4103/1319-3767.91734
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