Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously a...

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Detalles Bibliográficos
Autores principales: Ishibashi, Masaya, Fujimura, Taku, Hashimoto, Akira, Haga, Takahiro, Onami, Kaoru, Tsukada, Akira, Kambayashi, Yumi, Hidaka, Takanori, Furudate, Sadanori, Shimada, Ryoko, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published: January, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271839/
https://www.ncbi.nlm.nih.gov/pubmed/22308113
http://dx.doi.org/10.1159/000335999
Descripción
Sumario:We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

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