Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously a...

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Autores principales: Ishibashi, Masaya, Fujimura, Taku, Hashimoto, Akira, Haga, Takahiro, Onami, Kaoru, Tsukada, Akira, Kambayashi, Yumi, Hidaka, Takanori, Furudate, Sadanori, Shimada, Ryoko, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published: January, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271839/
https://www.ncbi.nlm.nih.gov/pubmed/22308113
http://dx.doi.org/10.1159/000335999
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author Ishibashi, Masaya
Fujimura, Taku
Hashimoto, Akira
Haga, Takahiro
Onami, Kaoru
Tsukada, Akira
Kambayashi, Yumi
Hidaka, Takanori
Furudate, Sadanori
Shimada, Ryoko
Aiba, Setsuya
author_facet Ishibashi, Masaya
Fujimura, Taku
Hashimoto, Akira
Haga, Takahiro
Onami, Kaoru
Tsukada, Akira
Kambayashi, Yumi
Hidaka, Takanori
Furudate, Sadanori
Shimada, Ryoko
Aiba, Setsuya
author_sort Ishibashi, Masaya
collection PubMed
description We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.
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spelling pubmed-32718392012-02-03 Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate Ishibashi, Masaya Fujimura, Taku Hashimoto, Akira Haga, Takahiro Onami, Kaoru Tsukada, Akira Kambayashi, Yumi Hidaka, Takanori Furudate, Sadanori Shimada, Ryoko Aiba, Setsuya Case Rep Dermatol Published: January, 2012 We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis. S. Karger AG 2012-01-11 /pmc/articles/PMC3271839/ /pubmed/22308113 http://dx.doi.org/10.1159/000335999 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: January, 2012
Ishibashi, Masaya
Fujimura, Taku
Hashimoto, Akira
Haga, Takahiro
Onami, Kaoru
Tsukada, Akira
Kambayashi, Yumi
Hidaka, Takanori
Furudate, Sadanori
Shimada, Ryoko
Aiba, Setsuya
Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
title Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
title_full Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
title_fullStr Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
title_full_unstemmed Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
title_short Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate
title_sort successful treatment of mmp-9-expressing angiosarcoma with low-dose docetaxel and bisphosphonate
topic Published: January, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271839/
https://www.ncbi.nlm.nih.gov/pubmed/22308113
http://dx.doi.org/10.1159/000335999
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