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The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells

The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential...

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Detalles Bibliográficos
Autores principales: Chifflet, Silvia, Hernández, Julio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272338/
https://www.ncbi.nlm.nih.gov/pubmed/22315611
http://dx.doi.org/10.1155/2012/121424
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author Chifflet, Silvia
Hernández, Julio A.
author_facet Chifflet, Silvia
Hernández, Julio A.
author_sort Chifflet, Silvia
collection PubMed
description The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis.
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spelling pubmed-32723382012-02-07 The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells Chifflet, Silvia Hernández, Julio A. Int J Cell Biol Review Article The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis. Hindawi Publishing Corporation 2012 2012-01-23 /pmc/articles/PMC3272338/ /pubmed/22315611 http://dx.doi.org/10.1155/2012/121424 Text en Copyright © 2012 S. Chifflet and J. A. Hernández. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chifflet, Silvia
Hernández, Julio A.
The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
title The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
title_full The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
title_fullStr The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
title_full_unstemmed The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
title_short The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
title_sort plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272338/
https://www.ncbi.nlm.nih.gov/pubmed/22315611
http://dx.doi.org/10.1155/2012/121424
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