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The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272338/ https://www.ncbi.nlm.nih.gov/pubmed/22315611 http://dx.doi.org/10.1155/2012/121424 |
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author | Chifflet, Silvia Hernández, Julio A. |
author_facet | Chifflet, Silvia Hernández, Julio A. |
author_sort | Chifflet, Silvia |
collection | PubMed |
description | The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis. |
format | Online Article Text |
id | pubmed-3272338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32723382012-02-07 The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells Chifflet, Silvia Hernández, Julio A. Int J Cell Biol Review Article The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis. Hindawi Publishing Corporation 2012 2012-01-23 /pmc/articles/PMC3272338/ /pubmed/22315611 http://dx.doi.org/10.1155/2012/121424 Text en Copyright © 2012 S. Chifflet and J. A. Hernández. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chifflet, Silvia Hernández, Julio A. The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
title | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
title_full | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
title_fullStr | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
title_full_unstemmed | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
title_short | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
title_sort | plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272338/ https://www.ncbi.nlm.nih.gov/pubmed/22315611 http://dx.doi.org/10.1155/2012/121424 |
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